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Acidic nuclear phosphoprotein 32A (human) monoclonal antibody (RJ1)

ALX-804-811-C100 100 µg 290.00 USD
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Product Specification

Alternative Name:HLA-DR associated protein 1, Acidic nuclear phosphoprotein pp32, HLA-DR-associated protein 1, PHAPI, PP2A inhibitor protein 1α, I1αPP2A, LANP, ANP32A
Immunogen:Recombinant human acidic nuclear phosphoprotein 32A.
UniProt ID:P39687
Source:Purified from concentrated hybridoma tissue culture supernatant.
Species reactivity:Human
Applications:ICC, IP, WB
Recommended Dilutions/Conditions:Immunocytochemistry (1:100-1:200)
Western Blot (1:4,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Works on endogenous.
Purity Detail:Protein G-affinity purified.
Formulation:Liquid. In PBS containing 0.02% sodium azide.
Handling:Avoid freeze/thaw cycles.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C

Product Literature References

Granzyme a induces caspase-independent mitochondrial damage, a required first step for apoptosis: D. Martinvalet, et al.; Immunity 22, 355 (2005), Abstract;
Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A: Z. Fan, et al.; Nat. Immunol. 4, 145 (2003), Abstract;
Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor: Z. Fan, et al.; Cell 112, 659 (2003), Abstract;
HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A: Z. Fan, et al.; Mol. Cell. Biol. 22, 2810 (2002), Abstract; Full Text
Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks: P.J. Beresford, et al.; J. Biol. Chem. 276, 43285 (2001), Abstract; Full Text

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