| ALX-804-806PF-C100 | 100 µg | 585.00 USD |  |
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| Alternative Name: | Lymphocyte activation gene-3, FDC protein, CD223 |
| Clone: | 17B4 |
| Host: | Mouse |
| Isotype: | IgG1 |
| Immunogen: | Synthetic peptide corresponding to 30 aa (GPPAAAPGHPLAPGPHPAAPSSWGPRPRRY) from the first N-terminal D1 domain of human LAG-3 (lymphocyte activation gene-3). |
| UniProt ID: | P18627 |
| Source: | Purified from hybridoma tissue culture supernatant. |
| Species reactivity: | Human |
| Specificity: | Recognizes the 30 aa extra-loop of the first N-terminal D1 domain of LAG-3. |
| Applications: | Flow Cytometry, ICC, IHC, IP, WB, FUNC |
| Recommended Dilutions/Conditions: | Immunohistochemistry (frozen sections, 1:150) Immunoprecipitation (10µg/ml) Western Blot (5µg/ml) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Functional Application: Inhibition |
| Purity Detail: | Purified from concentrated hybridoma tissue culture supernatant by Protein A Sepharose™ CL-4B Flow Fast Column. |
| Endotoxin Content: | < 1 EU/mg of protein. |
| Formulation: | Liquid. In PBS containing 10% glycerol. |
| Use/Stability: | Stable for at least 1 year after receipt when stored at -20°C. |
| Handling: | Avoid freeze/thaw cycles. |
| Shipping: | Blue Ice |
| Short Term Storage: | +4°C |
| Long Term Storage: | -20°C |
| Scientific Background: | The lymphocyte activation gene-3 (LAG-3, CD223), a member of the immunoglobulin superfamily (IgSF) related to CD4, binds to the major histocompatibility complex (MHC) class II molecules but with higher affinity than CD4. Several alternative mRNA splice-variants of human LAG-3 have been described, two of them encoding potential secreted forms: LAG-3V1 (i.e. the D1-D2 domains of the protein, 36 kDa) and LAG-3V3 (D1-D3, 52 kDa). The longer form was detected by ELISA in the serum of healthy individuals as well as of tuberculosis patients with a favorable outcome. LAG-3 expression by T cell clones correlated with IFN-γ production, and hence soluble LAG-3 has been suggested as a serological marker of Th1 responses. |
| Technical Info/Product Notes: | SEPHAROSE is a trademark of GE Healthcare companies. |
| Regulatory Status: | RUO - Research Use Only |
LAG-3 (human) monoclonal antibody (17B4) (biotin conjugate) |
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| Purified from hybridoma tissue culture supernatant., ELISA, WB | Print as PDF | ||||||
| ALX-804-806B-C100 | 100 µg | Biotin | 626.00 USD | |
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LAG-3 (human) monoclonal antibody (17B4) (FITC conjugate) |
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| Purified from hybridoma tissue culture supernatant., Flow Cytometry | Print as PDF | ||||||
| ALX-804-806F-C100 | 100 µg | FITC | 625.00 USD | |
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LAG-3 (human) monoclonal antibody (17B4) (ATTO 488 conjugate) |
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| Purified from hybridoma tissue culture supernatant., Flow Cytometry, ICC | Print as PDF | ||||||
| ALX-804-806TD-T100 | 100 tests | ATTO 488 | 649.00 USD | |
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LAG-3 (human) monoclonal antibody (17B4) (ATTO 647N conjugate) |
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| Purified from hybridoma tissue culture supernatant., Flow Cytometry, ICC | Print as PDF | ||||||
| ALX-804-806TS-T100 | 100 tests | ATTO 647N | 508.00 USD | |
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LAG-3 (human) monoclonal antibody (17B4) |
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| Purified from hybridoma tissue culture supernatant., ICC, IHC, IP, WB | Print as PDF | ||||||
| ALX-804-806-C100 | 100 µg | 533.00 USD | |
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| Do you need bulk/larger quantities? | ||||||
