Alternative Name: | Erg1, Ether-a-go-go related protein 1, KCNH2, Voltage-gated potassium channel subfamily H member 2, Voltage-gated potassium channel Kv11.1 |
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Clone: | A12 |
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Host: | Mouse |
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Isotype: | IgG2b |
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Immunogen: | Synthetic peptide corresponding to aa 575-588 (E575QPHMDSRIGWLHN588) of the extracellular loop S5-P of HERG1 (human ether-a-go-go related protein 1). |
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UniProt ID: | Q12809 |
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Species reactivity: | Human
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Specificity: | Recognizes the extracellular loop S5-P of HERG1. |
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Applications: | Flow Cytometry, ICC, IHC (PS), IP
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Recommended Dilutions/Conditions: | Flow Cytometry (1:2-1:50) Immunocytochemistry (1:200-1:1,000) Immunohistochemistry (paraffin sections, 1:50-1:200) Immunoprecipitation (3-5µl) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Formulation: | Liquid. Sterile DMEM medium containing 10% bovine calf serum. |
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Handling: | Avoid freeze/thaw cycles. |
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Shipping: | Shipped on Blue Ice |
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Short Term Storage: | +4°C |
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Long Term Storage: | -20°C |
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Scientific Background: | The ether-a-go-go related gene family of K+ channels (HERG/Erg) comprises three members, HERG1/Erg1, HERG2/Erg2, HERG3/Erg3. HERG channel activity is relevant to tumor cell biology. It controls cell proliferation, especially in leukaemias. HERG channels are thus considered diagnostic and prognostic factors in human cancers, as well as targets for anti-neoplastic therapies. |
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Regulatory Status: | RUO - Research Use Only |
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