| ALX-804-632-L001 | 1 ml | 200.00 USD |  |
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| Alternative Name: | Myc proto-oncogene, Transcription factor p64 |
| Clone: | 6A10 |
| Host: | Rat |
| Isotype: | IgG2a |
| Immunogen: | Human c-Myc (aa 1-262). |
| UniProt ID: | P01106 |
| Species reactivity: | Human |
| Applications: | ICC, IP, WB |
| Recommended Dilutions/Conditions: | Immunocytochemistry (1:10) Immunoprecipitation (1:10) Western Blot (1:50) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Formulation: | Liquid. Tissue culture supernatant (TCS) containing 0.1% sodium azide. |
| Use/Stability: | Stable for at least 1 year when stored at +4°C. |
| Handling: | Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | +4°C |
| Scientific Background: | Myc proteins are important regulators of cell behaviour and work as transcription factors that belong to the basic region/helix-loop-helix/leucine zipper family of DNA binding proteins. To regulate its target genes, Myc recruits several different cofactors (e.g. PARP-10). They control a variety of cellular functions including protein synthesis, cell cycle progression, and apoptosis, thereby modulating cell growth and proliferation, differentiation, and survivial of cells. The family of myc genes includes B-myc, L-myc, N-myc and s-myc; however only c-myc, L-myc and N-myc have neoplastic potential. The c-Myc gene was discovered as the cellular homolog of the retroviral v-myc oncogene. It is a proto-oncogene, whereas the deregulated expression of c-Myc is observed in the majority of human and animal tumors often with poor prognosis. The proto-oncogene c-Myc is implicated in various physiological processes; cell growth, proliferation, loss of differentiation and cell death (apoptosis). It also has been implicated in the loss and dysfunction of insulin-producing beta cells in diabetes. Studies in mice suggest that c-Myc has unexpected functions during both self-renewal and the differentiation of stem and early progenitor cells. c-Myc activity is normally tightly controlled by external signals including growth factors, mitogens and β-catenin which promote, and factors as TGF-beta which inhibit. |
| Regulatory Status: | RUO - Research Use Only |
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