Product Details
Clone: | APS 18 |
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Host: | Mouse |
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Isotype: | IgG1 |
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Immunogen: | Synthetic peptide corresponding to aa 313-334 (S313KYNAESTER ESQDTVAENDDG334) of C-terminal human presenilin 1. |
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UniProt ID: | P49768 |
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Species reactivity: | Human, Mouse, Rat Monkey
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Crossreactivity: | Does not cross-react with presenilin 2. |
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Applications: | ELISA, ICC, WB
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Recommended Dilutions/Conditions: | ELISA (1µg/ml) Immunocytochemistry (6µg/ml) Western Blot (12µg/ml) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Application Notes: | Detects a band of ~18kDa (C-terminal fragment) and ~46kDa (full-length) presenilin 1 by Western blot. |
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Purity Detail: | Protein G affinity purified. |
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Formulation: | Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide. |
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Handling: | Avoid freeze/thaw cycles. |
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Shipping: | Blue Ice |
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Long Term Storage: | -20°C |
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Regulatory Status: | RUO - Research Use Only |
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Figure: Immunocytochemistry using MAb to Presenilin 1 (APS 18) (Prod. No.
ALX-804-555) shows endogenous presenilin 1 staining in Golgi and cellular vesicles in 4% paraformaldehyde fixed N2a cells."
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Product Literature References
Analysis of presenilin 1 and presenilin 2 expression and processing by newly developed monoclonal antibodies: A. Diehlmann, et al.; J. Neurosci. Res.
56, 405 (1999),
Abstract;
Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071: B. Stahl, et al.; J. Biol. Chem.
274, 9141 (1999),
Abstract;
Abrogation of the presenilin 1/beta-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation: G. Tesco, et al.; J. Biol. Chem.
273, 33909 (1998),
Abstract;