Product Specification
| Alternative Name: | TLR3, CD283 |
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| Clone: | TLR3.7 |
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| Host: | Mouse |
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| Isotype: | IgG1 |
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| Immunogen: | Recombinant human TLR3 (Toll-like receptor 3). |
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| UniProt ID: | O15455 |
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| Source: | Purified from hybridoma tissue culture supernatant. |
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| Species reactivity: | Human
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| Applications: | Flow Cytometry, ICC, IP, FUNC
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| Application Notes: | Functional Application: blocks double-stranded RNA-mediated signalling |
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| Formulation: | Liquid. Purified antibody in PBS containing 10% glycerol. Does not contain any preservatives. |
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| Use/Stability: | Stable for at least 1 year after receipt when stored as recommended. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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Figure: Clone TLR3.7 inhibits dsRNA-induced IFN-b production by MRC-5 cells.
Figure: Immunoprecipitation of human TLR3 in transfectants with clone TLR3.7.
Figure: FC with clone TLR3.7.
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Product Literature References
Mechanism of up-regulation of human Toll-like receptor 3 secondary to infection of measles virus-attenuated strains: M. Tanabe, et al.; BBRC
311, 39 (2003),
Abstract;
Subcellular localization of Toll-like receptor 3 in human dendritic cells: M. Matsumoto, et al.; J. Immunol.
171, 3154 (2003),
Abstract;
Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling: M. Matsumoto, et al.; BBRC
293, 1364 (2002),
Abstract;
