| Alternative Name: | TLR8, CD288 |
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| Clone: | 44C143 |
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| Host: | Mouse |
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| Isotype: | IgG1 |
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| Immunogen: | Synthetic peptide corresponding to aa 750-850 of the cytoplasmic portion of human TLR8 (Toll-like receptor 8). |
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| UniProt ID: | Q9NR97 |
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| Species reactivity: | Human, Mouse
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| Applications: | Flow Cytometry
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| Recommended Dilutions/Conditions: | Flow Cytometry (intracellular, 0.5-2µg per 106 cells; cell surface: see Xu et al. (2006) for details)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Application Notes: | Detects a band of ~120kDa by Western blot. |
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| Purity Detail: | Protein G-affinity purified. |
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| Formulation: | Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide. |
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| Handling: | Do not freeze. Protect from light. |
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| Shipping: | Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | +4°C |
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| Scientific Background: | The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. Ten human homologs of TLRs (TLR1-10) have been described. TLR8 gene contains three exons, two of which have coding function. TLR8 cDNA codes for a protein of approximate molecular weight of 120kDa. |
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| Technical Info/Product Notes: | Replacement for ADI-CSA-825 |
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| Regulatory Status: | RUO - Research Use Only |
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