Product Details
| Alternative Name: | TBK1, T2K, NF-κB-activating kinase, NAK |
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| Clone: | 108A429 |
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| Host: | Mouse |
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| Isotype: | IgG1 |
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| Immunogen: | Synthetic peptide corresponding to aa 563-577 (YYQFKKDKAERRLAYC) of human TBK1 (TANK-binding kinase 1). |
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| UniProt ID: | Q9UHD2 |
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| Species reactivity: | Human, Mouse, Rat
Bovine, Dog
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| Applications: | WB
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| Recommended Dilutions/Conditions: | Western Blot (1-2µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Application Notes: | Detects a band of ~80kDa by Western blot. |
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| Purity Detail: | Protein G-affinity purified. |
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| Formulation: | Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide. |
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| Shipping: | Shipped on Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Scientific Background: | TANK-binding Kinase 1 (TBK1) is a member of the IKK family. TANK (TRAF-associated NF-κB activator) interacts with TBK1 and activates NF-κB in a kinase-dependent manner. |
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| Regulatory Status: | RUO - Research Use Only |
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Figure 1: Western blot analysis of TBK1 using MAb to TANK-binding Kinase 1 (108A429) (Prod. No.
ALX-804-372) at 2μg/ml dilution against 10μg/lane of lysate from 293 cells untransfected (lane 1) and transfected with human TBK1 cDNA (lane 2)."
Figure 2: Western blot analysis of TBK in human Daudi cell lysate (A) and mouse RAW cell lysate (B) using MAb to TANK-binding Kinase 1 (108A429) (Prod. No.
ALX-.804-372) at 2μg/ml."
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Product Literature References
Gene expression and antiviral activity of alpha/beta interferons and interleukin-29 in virus-infected human myeloid dendritic cells: P. Osterlund, et al.; J. Virol.
79, 9608 (2005),
Abstract;
Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I: R. Sumpter, Jr., et al.; J. Virol.
79, 2689 (2005),
Abstract;
Full Text
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway: K.A. Fitzgerald, et al.; Nat. Immunol.
4, 491 (2003),
Abstract;
NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase: J.L. Pomerantz & D. Baltimore; EMBO J.
18, 6694 (1999),
Abstract;
Full Text
