Product Details
| Alternative Name: | TLR3, CD283 |
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| Clone: | 40C1285.6 |
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| Host: | Mouse |
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| Isotype: | IgG1 |
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| Immunogen: | Synthetic peptide corresponding to aa 55-70 (VLNLTHNQLRRLPAAN) of human TLR3 (Toll-like receptor 3) cytoplasmic portion. |
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| UniProt ID: | O15455 |
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| Species reactivity: | Human, Mouse
Dog
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| Applications: | Flow Cytometry, ICC, IHC (PS), IP, WB
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| Recommended Dilutions/Conditions: | Flow Cytometry (0.5-4µg/106 cells for intracellular staining)
Immunoprecipitation (2µg/106 transfected cells)
Western Blot (1-3µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Purity Detail: | Protein G-affinity purified. |
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| Formulation: | Liquid. In PBS containing 0.05% sodium azide. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Figure: Western blot analysis of TLR3 in lysates from untransfected 293 cells (lane A), 293 cells transfected with human TLR3 cDNA (lane B), and 20µg/lane human intestine tissue lysate (lane C).
Figure: Immunohistochemistry of human gut lumen (longitudinal section, transverse region) using MAb to Toll-like Receptor 3 (human) (40C1285.6) (Prod. No.
ALX-804-362) at 10µg/ml.
Data courtesy Dr. Elizabeth Furrie, University of Dundee."
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Product Literature References
Differential Effects of Nicotine, Alcohol, and Coexposure on Neuroimmune-Related Protein and Gene Expression in Corticolimbic Brain Regions of Rats: C.A. Randall, et al.; ACS Chem. Neurosci.
14, 628 (2023),
Abstract;
Biochemical and functional analyses of the human Toll-like receptor 3 ectodomain: C.T. Ranjith-Kumar, et al.; J. Biol. Chem.
282, 7668 (2007),
Abstract;
Full Text
Effects of single nucleotide polymorphisms on Toll-like receptor 3 activity and expression in cultured cells: C.T. Ranjith-Kumar, et al.; J. Biol. Chem.
282, 17696 (2007),
Abstract;
Full Text
Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils: C.K. Wong, et al.; Am. J. Respir. Cell Mol. Biol.
37, 85 (2007),
Abstract;
Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes: K. Li, et al.; J. Biol. Chem.
280, 16739 (2005),
Abstract;
Full Text
Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: linking innate and adaptive immune responses: T.A. Schneeman, et al.; J. Immunol.
175, 376 (2005),
Abstract;
Thyrocytes express a functional toll-like receptor 3: overexpression can be induced by viral infection and reversed by phenylmethimazole and is associated with Hashimoto’s autoimmune thyroiditis: N. Harii, et al.; Mol. Endocrinol.
19, 1231 (2005),
Abstract;
Toll-like receptors-2, -3 and -4 expression patterns on human colon and their regulation by mucosal-associated bacteria: E. Furrie, et al.; Immunology
115, 565 (2005),
Abstract;
The effect of innate immunity on autoimmune diabetes and the expression of Toll-like receptors on pancreatic islets: L. Wen, et al.; J. Immunol.
172, 3173 (2004),
Abstract;
Subcellular localization of Toll-like receptor 3 in human dendritic cells: M. Matsumoto, et al.; J. Immunol.
171, 3154 (2003),
Abstract;
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