Product Details
Clone: | 10C6 |
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Host: | Rat |
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Isotype: | IgG2a |
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Immunogen: | Recombinant human caspase-2 (p19 subunit). |
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UniProt ID: | P42575 |
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Species reactivity: | Human, Mouse, Rat Dog, Monkey
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Specificity: | Recognizes an epitope in the p19 subunit of human, mouse, rat, monkey and dog caspase-2. |
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Applications: | ELISA, Flow Cytometry, ICC, IHC (FS)
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Recommended Dilutions/Conditions: | Flow Cytometry (1µg/ml) Immunocytochemistry (10-20µg/ml; fix in 4% paraformaldehyde, 0.18% Triton-X100 for 10 min. prior to staining) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Purity Detail: | Protein G-affinity purified. |
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Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
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Handling: | Avoid freeze/thaw cycles. |
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Shipping: | Blue Ice |
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Short Term Storage: | +4°C |
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Long Term Storage: | -20°C |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Caspase-2 resides in the mitochondria and mediates apoptosis directly from the mitochondrial compartment: M. Lopez-Cruzan, et al.; Cell Death Discov.
2, 16005 (2016),
Application(s): Immunocytochemistry,
Abstract;
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Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death: V.S. Marsden, et al.; Blood
107, 1872 (2006),
Abstract;
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Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation: C.L. Scott, et al.; J. Cell Biol.
164, 89 (2004),
Abstract;
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Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9: L.A. OReilly, et al.; Cell Death Differ.
9, 832 (2002),
Abstract;
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