Product Details
| Alternative Name: | BCL2L2 |
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| Clone: | 13F9 |
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| Host: | Rat |
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| Isotype: | IgG2a |
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| Immunogen: | Recombinant human Bcl-w. |
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| UniProt ID: | Q92843 |
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| Species reactivity: | Human, Mouse, Rat
Dog, Monkey
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| Applications: | IP, WB
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| Application Notes: | Excellent for Immunoprecipitation. |
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| Purity Detail: | Protein G-affinity purified. |
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| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Shipped on Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Figure: Immunoprecipitation/Western blot showing the detection of Bcl-w in human and mouse cell lines. Lysates from 107 cells were immunoprecipitated by clone 13F9 and the fractionated proteins were then blotted with the same antibody. Hsp-70 expression was used as an equal loading control, and 293T cells transiently transfected with a human bcl-w expression construct were used as a positive control.
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Product Literature References
Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic: J. Kuroda, et al.; PNAS
103, 14907 (2006),
Abstract;
Full Text
Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity: J. Wilson-Annan, et al.; J. Cell Biol.
162, 877 (2003),
Abstract;
Full Text
Tissue expression and subcellular localization of the pro-survival molecule Bcl-w: L.A. O'Reilly, et al.; Cell Death Differ.
8, 486 (2001),
Abstract;
Bcl-w is an important determinant of damage-induced apoptosis in epithelia of small and large intestine: D.M. Pritchard, et al.; Oncogene
19, 3955 (2000),
Abstract;
