| ALX-804-286-R100 | 100 µl | 722.00 USD |  |
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| Clone: | Mab9 |
| Host: | Mouse |
| Isotype: | IgG1 |
| Immunogen: | Recombinant dog Rab 9. |
| UniProt ID: | P24408 |
| Species reactivity: | Human, Rat Bovine, Dog, Hamster, Monkey |
| Crossreactivity: | Does not cross-react with other Rab family members. |
| Applications: | ICC, IP, WB |
| Recommended Dilutions/Conditions: | Immunocytochemistry (1:500),Western Blot (1:1,000) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~26kDa by Western blot. |
| Formulation: | Liquid. Ascites diluted in PBS containing 0.05% sodium azide. |
| Handling: | Avoid freeze/thaw cycles. |
| Shipping: | Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | Rab proteins are a family of Ras-like GTPases involved in intracellular compartment protein transport. Different members of the 40+ member rab family are responsible for docking and fusion of transport vesicles between different compartments within the cell. Rab 9 is required for trafficking mannose 6-phosphate receptor between the late endosome to trans-Golgi network (TGN). By facilitating receptor transport, rab 9 enables cells to efficiently recycle important cellular trafficking components. It is functionally necessary for rab 9, like other rab family members, to be prenylated by two 20-carbon geranylgeranyl groups at the C-terminus. Most prenylated rab 9 is membrane bound, however, 10-20% of the cellular pool of rab 9 is bound to GDP dissociation inhibitor-alpha (GDI-alpha) in the cytosol. GDI recycles prenylated, GDP bound rab 9 from their fusion targets back to their membranes of origin. |
| Regulatory Status: | RUO - Research Use Only |
