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United States 

Bax (human) monoclonal antibody (2D2)

ALX-804-225-C100 100 µg 375.00 USD
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Replaces Prod. #: BML-SA385

Product Details

Alternative Name:BCL2L4, BCL2-associated X protein
Immunogen:Synthetic peptide corresponding to aa 3-16 of human Bax.
UniProt ID:Q07812
Species reactivity:Human
Specificity:Recognizes Bax independent of its conformational state.
Applications:ELISA, ICC, IP, WB
Recommended Dilutions/Conditions:ELISA (0.5-1µg/ml)
Immunocytochemistry (0.5-1µg/ml)
Immunoprecipitation (in detergent)
Western Blot (0.5-1µg/ml). Suggested dilutions/conditions may not be available for all applications. Optimal should be determined individually for each application.
Formulation:Liquid. In PBS.
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Shipping:Blue Ice
Long Term Storage:+4°C
Scientific Background:Bax and Bak operate in both the endoplasmatic reticulum (ER) and mitochondria as an essential gateway for selected apoptotic signals. A role for Bcl-2 at the ER has been suggested earlier as Bcl-2 may regulate calcium fluxes between the ER and the mitochondria. For a review on Ca2+ and its role in apoptosis.
Regulatory Status:RUO - Research Use Only

Product Literature References

Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis: J.A. Yethon, et al.; J. Biol. Chem. 278, 48935 (2003), Abstract;
Direct addition of BimL to mitochondria does not lead to cytochrome c release: O. Terradillos, et al.; FEBS Lett. 522, 29 (2002), Abstract;
Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis: Y.T. Hsu, et al.; PNAS 94, 3668 (1997), Abstract; Full Text
Movement of Bax from the cytosol to mitochondria during apoptosis: K.G. Wolter et al.; J. Cell. Biol. 139, 1281 (1997), Abstract;
Nonionic detergents induce dimerization among members of the Bcl-2 family: Y.T. Hsu and R.J. Youle; J. Biol. Chem. 272, 13829 (1997), Abstract; Full Text

General Literature References

BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis: L. Scorrano, et al.; Science 300, 135 (2003), Abstract;
Calcium signaling and apoptosis: G. Hajnoczky, et al.; BBRC 304, 445 (2003), Abstract;
New insights in the role of Bcl-2 Bcl-2 and the endoplasmic reticulum: J. Rudner, et al.; Apoptosis 7, 441 (2002), Abstract;

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