| ALX-804-225-C100 | 100 µg | 375.00 USD |  |
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| Alternative Name: | BCL2L4, BCL2-associated X protein |
| Clone: | 2D2 |
| Host: | Mouse |
| Isotype: | IgG1 |
| Immunogen: | Synthetic peptide corresponding to aa 3-16 of human Bax. |
| UniProt ID: | Q07812 |
| Species reactivity: | Human |
| Specificity: | Recognizes Bax independent of its conformational state. |
| Applications: | ELISA, ICC, IP, WB |
| Recommended Dilutions/Conditions: | ELISA (0.5-1µg/ml) Immunocytochemistry (0.5-1µg/ml) Immunoprecipitation (in detergent) Western Blot (0.5-1µg/ml). Suggested dilutions/conditions may not be available for all applications. Optimal should be determined individually for each application. |
| Formulation: | Liquid. In PBS. |
| Handling: | Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. |
| Shipping: | Blue Ice |
| Long Term Storage: | +4°C |
| Scientific Background: | Bax and Bak operate in both the endoplasmatic reticulum (ER) and mitochondria as an essential gateway for selected apoptotic signals. A role for Bcl-2 at the ER has been suggested earlier as Bcl-2 may regulate calcium fluxes between the ER and the mitochondria. For a review on Ca2+ and its role in apoptosis. |
| Regulatory Status: | RUO - Research Use Only |
