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Human IgG1 Isotype Control

ALX-804-133-C100 100 µg 304.00 USD
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Human IgG1 are purified from human plasma by fractionation, ion exchange and affinity chromatography. The purified IgG represent a single subclass and light chain type (κ).  Source material has been shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests. Negative control in experiments with recombinant proteins fused to human IgG1 Fc.

Product Details

Source:Purified from human plasma.
Species reactivity:Species independent
Applications:ELISA, Flow Cytometry, IP, WB
Application Notes:Negative control in assays where receptors:Fc (IgG1) are used.
Purity Detail:Purified from myeloma plasma.
Endotoxin Content:<0.1EU/µg antibody (LAL test; BioWhittaker)
Formulation:Lyophilized from PBS, pH 7.2.
Reconstitution:Reconstitute with 100µl sterile water.
Use/Stability:Stable for at least 1 year after receipt when stored as recommended.
Shipping:Blue Ice
Long Term Storage:+4°C
Technical Info/Product Notes:Cited samples:
For an overview on cited samples please click here.
Regulatory Status:RUO - Research Use Only

Product Literature References

Development of DS-5573a: A novel afucosylated mAb directed at B7-H3 with potent antitumor activity: A. Nagase-Zembutsu, et al.; Cancer Sci. 107, 674 (2016), Application(s): Flow cytometry, Abstract; Full Text
Novel anti-EPHA2 antibody, DS-8895a for cancer treatment: J. Hasegawa, et al.; Cancer Biol. Ther. 17, 1158 (2016), Abstract; Full Text
Cutting Edge: PD-1 Regulates Imiquimod-Induced Psoriasiform Dermatitis through Inhibition of IL-17A Expression by Innate γδ-Low T Cells: Y. Imai, et al.; J. Immunol. 195, 421 (2015), Abstract; Full Text
T cells bearing a chimeric antigen receptor against prostate-specific membrane antigen mediate vascular disruption and result in tumor regression: S.P. Santoro, et al.; Cancer Immunol. Res. 3, 68 (2015), Abstract; Full Text
Specific Notch receptor–ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength: I. van de Walle, et al.; J. Exp. Med. 210, 683 (2013), Application(s): Binding studies using human K562 cells, Abstract; Full Text
TLR3 agonists improve the immunostimulatory potential of cetuximab against EGFR+ head and neck cancer cells: C. Ming Lim, et al.; Oncoimmunology 2, e24677 (2013), Application(s): 51Cr release assay using human peripheral blood monocytes (PBMCs), Abstract; Full Text
Fc gamma receptor CD64 modulates the inhibitory activity of infliximab: K.A. Wojtal, et al.; PLoS One 7, e43361 (2012), Application(s): FC receptor blocking of human fibroblasts and THP-1 cells, Abstract; Full Text
Development of a serum biomarker assay that differentiates tumor-associated MUC5AC (NPC-1C ANTIGEN) from normal MUC5AC: J. Luka, et al.; J. Biomed. Biotechnol. 2011, 934757 (2011), Abstract; Full Text
A subset of myeloid dendritic cells derived from peripheral blood monocytes represented a predominant subset characterized by their potential tumor-inhibiting activity: M. Wang, et al.; In Vitro Cell Dev. Biol. Anim. 45, 398 (2009), Abstract;
Enhanced exposure of the CD4-binding site to neutralizing antibodies by structural design of a membrane-anchored human immunodeficiency virus type 1 gp120 domain: L. Wu, et al.; J. Virol. 83, 5077 (2009), Abstract; Full Text
Use of fluorescent labeled anti-epidermal growth factor receptor antibody to image head and neck squamous cell carcinoma xenografts: E.L. Rosenthal, et al.; Mol. Cancer Ther. 6, 1230 (2007), Abstract; Full Text
Neutralization of TRAIL death pathway protects human neuronal cell line from beta-amyloid toxicity: G. Cantarella, et al.; Cell Death Differ. 10, 134 (2003), Abstract; Full Text

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