| ALX-804-023-R100 | 100 µl | 722.00 USD |  |
||
| Do you need bulk/larger quantities? | |||||
| Alternative Name: | Progesterone receptor complex p23, Telomerase-binding protein p23 |
| Clone: | JJ3 |
| Host: | Mouse |
| Isotype: | IgG2a |
| Immunogen: | Recombinant human HSP90 Co-chaperone. |
| UniProt ID: | Q15185 |
| Species reactivity: | Human, Mouse Chicken, Guinea pig, Rabbit |
| Applications: | ICC, IP, WB |
| Recommended Dilutions/Conditions: | Immunoprecipitation (use on free or complexed HSP90 Co-chaperone) Western Blot (1:1,000) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~23kDa by Western blot. |
| Formulation: | Liquid. Ascites diluted in PBS containing 0.05% sodium azide. |
| Handling: | Avoid freeze/thaw cycles. |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Prior to activation, steroid receptors associate with a number of different proteins in both a stable and transient fashion. Steroid receptor complex proteins include heat shock proteins (HSP70 and HSP90), immunosuppressant binding proteins called immunophilins (the FK506 binding proteins, FKBP52 & FKBP54 and the cyclosporin binding protein, CyP-40) and at least three other proteins termed p23, p60 and p48. p23 along with HSP70, HSP90 and p60, combine with progesterone receptor (PR) as members of a transient intermediate complex. Cloned human p23 encodes a protein of 160 aa that is highly conserved between species and shows no homology to previously identified proteins. p23 is a highly acidic phosphoprotein with an aspartic acid-rich C-terminal domain and multiple potential phosphorylation sites. In vitro studies have suggested that p23 binds to HSP90 and is necessary for the binding of HSP90 and CyP-40 to PR. While neither its exact function nor mechanism of action have been identified, p23 appears to be an important factor in PR function. |
| Regulatory Status: | RUO - Research Use Only |
 |
|
| Download as PDF | |
