Product Specification
| Alternative Name: | LY96, Lymphocyte antigen 96, ESOP-1 |
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| Clone: | 10A8 |
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| Host: | Mouse |
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| Isotype: | IgG1 |
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| Immunogen: | Recombinant human MD-2. |
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| UniProt ID: | Q9Y6Y9 |
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| Source: | Purified from concentrated hybridoma tissue culture supernatant. |
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| Species reactivity: | Human
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| Specificity: | Recognizes all forms of soluble human MD-2, but not membrane bound MD-2. |
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| Crossreactivity: | Does not cross-react with mouse MD-2. |
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| Applications: | ELISA, WB
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| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
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| Use/Stability: | Stable for at least 1 year after receipt when stored at -20°C. |
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| Handling: | Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. |
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| Shipping: | Shipped on Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Scientific Background: | The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. Toll-like receptor 4 (TLR4), the principal signaling receptor for lipopolysaccharide (LPS) in mammals, requires the binding of MD-2 to its extracellular domain for maximal responsiveness. MD-2 enables TLR4 to respond to a wide variety of LPS partial structures, Gram-negative bacteria, and Gram-positive lipoteichoic acid, but not to Gram-positive bacteria, peptidoglycan, and lipopeptide. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Characterization of monoclonal antibodies to human soluble MD-2 protein: S. Viriyakosol, et al.; Hybridoma
25, 349 (2006),
Abstract;
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