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Purinergic receptor P2X7 (mouse) monoclonal antibody (HANO43)

ALX-802-027-L001 1 ml 569.00 USD
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Product Details

Alternative Name:P2X purinoceptor 7, P2RX7
Immunogen:Vector containing the cDNA of mouse purinergic receptor P2X7.
UniProt ID:Q9Z1M0
Species reactivity:Mouse
Applications:Flow Cytometry, ICC, IP
Recommended Dilutions/Conditions:Flow Cytometry (1:1-1:10)
Immunocytochemistry (1:1-1:10)
Immunoprecipitation (1:1-1:10)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Positive Control:HEK cells transfected with an expression plasmid for mouse purinergic receptor P2X7 can be used as positive control.
Formulation:Liquid. Hybridoma supernatant containing 0.02% sodium azide.
Shipping:Blue Ice
Long Term Storage:+4°C
Regulatory Status:RUO - Research Use Only

Product Literature References

Positive allosteric modulation of P2X7 promotes apoptotic cell death over lytic cell death responses in macrophages: S. Bidula, et al.; Cell Death Dis. 10, 882 (2019), Abstract; Full Text
Testing the role of P2X7 receptors in the development of type 1 diabetes in nonobese diabetic mice: Y.G. Chen, et al.; J. Immunol. 186, 4278 (2011), Abstract;
Murine epidermal Langerhans cells and keratinocytes express functional P2X7 receptors: J.N. Tran, et al.; Exp. Dermatol. 19, e151 (2010), Abstract; Full Text
ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site: S. Adriouch, et al.; FASEB J. 22, 861 (2007), Abstract; Full Text
Monitoring the expression of purinoceptors and nucleotide-metabolizing ecto-enzymes with antibodies directed against proteins in native conformation: S. Möller, et al.; Purinergic Signal. 3, 359 (2007), Abstract; Full Text
P2X7 receptor expression levels determine lethal effects of a purine based danger signal in T lymphocytes: F. Aswad & G. Dennert; Cell. Immunol. 243, 58 (2006), Abstract;
Probing the expression and function of the P2X7 purinoceptor with antibodies raised by genetic immunization: S. Adriouch, et al.; Cell. Immunol. 236, 72 (2005), Abstract;

General Literature References

The P2X7 receptor: a key player in IL-1 processing and release: D. Ferrari, et al.; J. Immunol. 176, 3877 (2006), (Review), Abstract;
Molecular properties of ATP-gated P2X receptor ion channels: C. Vial, et al.; Trends Pharmacol. Sci. 25, 487 (2004), (Review), Abstract;
Molecular structure of P2X receptors: T.M. Egan, et al.; Curr. Top. Med. Chem. 4, 821 (2004), (Review), Abstract;
Molecular physiology of P2X receptors: R.A. North; Physiol. Rev. 82, 1013 (2002), (Review), Abstract;

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