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United States 

MRP4 monoclonal antibody (M4I-80)

ALX-801-039-C100 100 µg 420.00 USD
ALX-801-039-C200 200 µg 706.00 USD
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Product Details

Alternative Name:Multidrug resistance-associated protein 4, ABCC4
Immunogen:Recombinant human MRP4 (multidrug resistance-associated protein 4) (aa 372-431).
UniProt ID:O15439
Species reactivity:Human, Mouse
Applications:ICC, IHC (FS), WB
Recommended Dilutions/Conditions:Immunocytochemistry: Use 1:20-1:50 dilution on acetone fixed cytospin preparations.
Immunohistochemistry (frozen sections): Use 1:20 dilution on acetone fixed frozen sections followed by incubation with biotin-labelled rabbit anti-rat IgG and HRP-labelled streptavidin.
Western Blot: Use 1:20-1:50 dilution and HRP-anti-rat-IgG.
Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.
Application Notes:Immunocytochemistry: cytospin preparations
Formulation:Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide.
Shipping:Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only

Product Literature References

Optimization of an Oral Mucosa in vitro Model Based on Cell Line TR146: G.C. Lin, et al.; Tissue Barriers 21, 1748459 (2020), Abstract;
Serum-derived factors of breast cancer patients with brain metastases alter permeability of a human blood–brain barrier model: C.J. Curtaz, et al.; Fluids Barriers CNS 17, 31 (2020), Abstract; Full Text
Increased serum bile acid concentration following low-dose chronic administration of thioacetamide in rats, as evidenced by metabolomic analysis: E.S. Jeong, et al.; Toxicol. Appl. Pharmacol. 288, 213 (2015), Application(s): Western blot , Abstract;
Functionally overlapping roles of Abcg2 (Bcrp1) and Abcc2 (Mrp2) in the elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate in vivo: M.L. Vlaming et al.; Clin. Cancer Res. 15, 3084 (2009), Abstract;
Impact of Abcc2 (Mrp2) and Abcc3 (Mrp3) on the in vivo elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate: M.L. Vlaming et al.; Clin. Cancer Res. 14, 8152 (2008), Abstract;
Mrp4 confers resistance to topotecan and protects the brain from chemotherapy: M. Leggas, et al.; Mol. Cell. Biol. 24, 7612 (2004), Abstract;

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