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United States 

MRP4 monoclonal antibody (M4I-10)

ALX-801-038-C075 75 µg 569.00 USD
ALX-801-038-C150 150 µg 1,002.00 USD
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Product Details

Alternative Name:Multidrug resistance-associated protein 4, ABCC4
Immunogen:Recombinant human MRP4 (multidrug resistance-associated protein 4) (aa 372-431).
UniProt ID:O15439
Species reactivity:Human, Mouse
Applications:ICC, IHC (FS), WB
Recommended Dilutions/Conditions:Immunocytochemistry: Use 1:20-1:50 dilution on acetone fixed cytospin preparations.
Immunohistochemistry (frozen sections): Use 1:20 dilution on acetone fixed frozen sections followed by incubation with biotin-labelled rabbit anti-rat IgG and HRP-labelled streptavidin.
Western Blot: Use 1:20-1:50 dilution and HRP-anti-rat-IgG.
Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.
Application Notes:Immunocytochemistry: cytospin preparations
Formulation:Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide.
Shipping:Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only

Product Literature References

Alteration of human hepatic drug transporter activity and expression by cigarette smoke condensate: K. Sayyed, et al.; Toxicology 363, 58 (2016), Application(s): Cell culture; Effects on ABC transporter activities, Abstract;
N-linked glycans do not affect plasma membrane localization of multidrug resistance protein 4 (MRP4) but selectively alter its prostaglandin E2 transport activity: M.F. Miah, et al.; Biochem. Biophys. Res. Commun. 469, 954 (2016), Application(s): Immunoblotting, Abstract;
Down-regulation of Na+/H+ Exchanger Regulatory Factor 1 Increases Expression and Function of Multidrug Resistance Protein 4: M.T. Hoque & S.P. Cole; Cancer Res. 68, 4802 (2008), Abstract; Full Text
Mrp4 confers resistance to topotecan and protects the brain from chemotherapy: M. Leggas, et al.; Mol. Cell. Biol. 24, 7612 (2004), Abstract;

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