Product Details
Alternative Name: | BCRP, ABCG2, MXR, CD338 |
|
Clone: | BXP-53 |
|
Host: | Rat |
|
Isotype: | IgG2a |
|
Immunogen: | Recombinant mouse BCRP (breast cancer resistance protein; MXR) (aa 221-394). |
|
UniProt ID: | Q7TMS5 |
|
Species reactivity: | Human, Mouse
|
|
Specificity: | Recognizes an internal epitope of BCRP. |
|
Applications: | ICC, IHC (FS), IHC (PS), WB
|
|
Recommended Dilutions/Conditions: | Immunocytochemistry: Use 1:20-1:50 dilution on acetone fixed cytospin preparations. Immunohistochemistry (frozen sections, paraffin sections): Use 1:20 on acetone fixed frozen sections followed by incubation with biotin-labelled rabbit anti-rat IgG and HRP-labelled streptavidin., Western Blot: Use 1:20-1:50 dilution and HRP-labelled anti-rat IgG. Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
|
Formulation: | Liquid. In PBS, containing 0.1% BSA, and 0.02% sodium azide. |
|
Shipping: | Blue Ice |
|
Short Term Storage: | +4°C |
|
Long Term Storage: | -20°C |
|
Regulatory Status: | RUO - Research Use Only |
|
Product Literature References
Blood-brain and retinal barriers show dissimilar ABC transporter impacts and concealed effect of P-glycoprotein on a novel verapamil influx carrier: H. Chapy, et al.; Br. J. Pharmacol.
173, 497 (2016),
Abstract;
Full Text
Beta-Amyloid Downregulates MDR1-P-Glycoprotein (Abcb1) Expression at the Blood-Brain Barrier in Mice: A. Brenn, et al.; Int. J. Alzheimers Dis.
2011, 690121 (2011),
Application(s): IHC using mouse brain tissue,
Abstract;
Full Text
The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria: J.W. Jonker, et al.; PNAS
99, 15649 (2002),
Abstract;
Full Text