Product Details
Alternative Name: | ABCB4 |
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Clone: | P3II-26 |
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Host: | Mouse |
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Isotype: | IgG2b |
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Immunogen: | MDR3 P-glycoprotein fragment (aa 629-692). |
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UniProt ID: | P21439 |
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Species reactivity: | Human
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Crossreactivity: | Does not cross-react with human P-glycoprotein. |
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Applications: | ICC, IHC (FS), WB
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Recommended Dilutions/Conditions: | Immunocytochemistry: Use 1:20-1:50 dilution on acetone fixed cytospin preparations. Immunohistochemistry (frozen sections): Use 1:20 dilution on acetone fixed frozen sections followed by incubation with rabbit anti-mouse IgG and a monoclonal mouse APAAP complex. Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Application Notes: | Immunocytochemistry: cytospin preparations Immunohistochemistry: Suitable for frozen sections, not recommended for paraffin sections. |
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Formulation: | Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide. |
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Shipping: | Blue Ice |
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Short Term Storage: | +4°C |
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Long Term Storage: | -20°C |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
MRCK-Alpha and Its Effector Myosin II Regulatory Light Chain Bind ABCB4 and Regulate Its Membrane Expression: A. Bruneau, et al.; Cells
11, 617 (2022),
Abstract;
Structural analogues of roscovitine rescue the intracellular traffic and the function of ER-retained ABCB4 variants in cell models: V. Vauthier, et al.; Sci. Rep.
9, 6653 (2019),
Abstract;
Full Text
Partial external biliary diversion in bile salt export pump deficiency: Association between outcome and mutation: P. Ellinger, et al.; World J. Gastroenterol.
23, 5295 (2017),
Application(s): Immunofluorescence staining of liver samples,
Abstract;
Full Text
Liver pathology in severe multidrug resistant 3 protein deficiency: a series of 10 pediatric cases: M. Vij, et al.; Ann. Diagn. Pathol.
2015, 277 (2015),
Application(s): Immunohistochemistry,
Abstract;
Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies: G.L. Scheffer, et al.; Cancer Res.
60, 5269 (2000),
Abstract;
Full Text