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United States 

MDR3 P-glycoprotein (human) monoclonal antibody (P3II-26)

ALX-801-028-1000 1000 µl 583.00 USD
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Product Details

Alternative Name:ABCB4
Immunogen:MDR3 P-glycoprotein fragment (aa 629-692).
UniProt ID:P21439
Species reactivity:Human
Crossreactivity:Does not cross-react with human P-glycoprotein.
Applications:ICC, IHC (FS), WB
Recommended Dilutions/Conditions:Immunocytochemistry: Use 1:20-1:50 dilution on acetone fixed cytospin preparations.
Immunohistochemistry (frozen sections): Use 1:20 dilution on acetone fixed frozen sections followed by incubation with rabbit anti-mouse IgG and a monoclonal mouse APAAP complex.
Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.
Application Notes:Immunocytochemistry: cytospin preparations
Immunohistochemistry: Suitable for frozen sections, not recommended for paraffin sections.
Formulation:Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide.
Shipping:Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only

Product Literature References

MRCK-Alpha and Its Effector Myosin II Regulatory Light Chain Bind ABCB4 and Regulate Its Membrane Expression: A. Bruneau, et al.; Cells 11, 617 (2022), Abstract;
Structural analogues of roscovitine rescue the intracellular traffic and the function of ER-retained ABCB4 variants in cell models: V. Vauthier, et al.; Sci. Rep. 9, 6653 (2019), Abstract; Full Text
Partial external biliary diversion in bile salt export pump deficiency: Association between outcome and mutation: P. Ellinger, et al.; World J. Gastroenterol. 23, 5295 (2017), Application(s): Immunofluorescence staining of liver samples, Abstract; Full Text
Liver pathology in severe multidrug resistant 3 protein deficiency: a series of 10 pediatric cases: M. Vij, et al.; Ann. Diagn. Pathol. 2015, 277 (2015), Application(s): Immunohistochemistry, Abstract;
Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies: G.L. Scheffer, et al.; Cancer Res. 60, 5269 (2000), Abstract; Full Text

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