Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Breast cancer resistance protein (human) monoclonal antibody (BXP-34)

ALX-801-027-C125 125 µg 567.00 USD
ALX-801-027-C250 250 µg 985.00 USD
Do you need bulk/larger quantities?

Product Details

Alternative Name:MXR, BCRP, ABCG2, CD338
Immunogen:Mitoxanthone resistant BCRP (breast cancer resistance protein; MXR) overexpressing cell line MCF7MR.
UniProt ID:Q9UNQ0
Species reactivity:Human
Specificity:Recognizes an internal epitope of human BCRP.
Crossreactivity:Does not cross-react with human P-glycoprotein, MRP1, MRP2 or MRP5.
Applications:Flow Cytometry, ICC, IHC (FS)
Recommended Dilutions/Conditions:Immunocytochemistry: Use 1:20-1:50 dilution on acetone fixed cytospin preparations.
Immunohistochemistry (frozen sections): Use 1:20 dilution of BXP-34 on acetone fixed frozen sections followed by incubation with rabbit anti-mouse IgG and a monoclonal mouse APAAP complex. BXP-34 cannot be used on formaldehyde-fixed paraffin-embedded human tissues and tumors.
Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.
Application Notes:Immunocytochemistry: cytospin preparations
Not recommended for Western blot.
Formulation:Liquid. In serum free cell culture supernatant containing 0.7% BSA and 0.1% sodium azide.
Shipping:Shipped on Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only

Product Literature References

Endocytosis of ABCG2 drug transporter caused by binding of 5D3 antibody: trafficking mechanisms and intracellular fate: M. Studzian, et al.; Biochim. Biophys. Acta 1853, 1759 (2015), Application(s): Immunofluorescence, Abstract;
The role of breast cancer resistance protein in acute lymphoblastic leukemia: S.L. Plasschaert, et al.; Clin. Cancer Res. 9, 5171 (2003), Abstract;
Breast cancer resistance protein expression and resistance to daunorubicin in blast cells from patients with acute myeloid leukaemia: J.M. Sargent, et al.; Br. J. Haematol. 115, 257 (2001), Abstract;
Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues: M. Maliepaard, et al.; Cancer Res. 61, 3458 (2001), Abstract; Full Text
Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone- and topotecan-resistant cell lines: G.L. Scheffer, et al.; Cancer Res. 60, 2589 (2000), Abstract; Full Text

General Literature References

A multidrug resistance transporter from human MCF-7 breast cancer cells: L.A. Doyle, et al.; PNAS 95, 15665 (1998), Abstract; Full Text

Related Literature

Product Flyers
Detect Activity of Major ABC Transporter Proteins
Detect Activity of Major ABC Transporter Proteins
Download as PDF

Stem Cells
Stem Cells
Download as PDF

All new literature pieces