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MRP5 (human) monoclonal antibody (M5II-54)



ALX-801-022-C250	250 µg	985.00 USD
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Product Details

Alternative Name:	Multidrug resistance-associated protein 5, ABCC5

Clone:	M₅II-54

Host:	Rat

Isotype:	IgG2a

Immunogen:	Recombinant human MRP5 (multidrug resistance-associated protein 5) (aa 722-911).

UniProt ID:	O15440

Species reactivity:	Human

Specificity:	Recognizes an internal epitope of human MRP5.

Crossreactivity:	Does not cross-react with human P-glycoprotein, MDR3 P-glycoprotein, MRP1, MRP2 (cMOAT) or MRP3.

Applications:	ICC, IHC (FS), WB

Recommended Dilutions/Conditions:	Immunocytochemistry: Use 1:20-50 dilution on acetone fixed cytospin preparations. Immunohistochemistry: Use 1:20 dilution on acetone fixed frozen sections followed by incubation with rabbit anti-rat IgG and a monoclonal rat APAAP complex. Alternatively, after incubation with primary antibody (use 1:20) and washing, slides can be incubated with biotinylated rabbit anti-rat IgG and streptavidin conjugated to horseradish peroxidase. Western Blot: Use 1:20-50 dilution and anti-rat-HRP. Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.

Application Notes:	Immunocytochemistry: cytospin preparations

Formulation:	Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide.

Handling:	Avoid freeze/thaw cycles.

Shipping:	Blue Ice

Short Term Storage:	+4°C

Long Term Storage:	-20°C

Regulatory Status:	RUO - Research Use Only

Product Literature References

Evaluation of transport of common antiepileptic drugs by human multidrug resistance-associated proteins (MRP1, 2 and 5) that are overexpressed in pharmacoresistant epilepsy: C. Luna-Tortos, et al.; Neuropharmacology 58, 1019 (2010), Abstract;

Multidrug resistance-associated proteins 3, 4, and 5: P. Borst, et al.; Pflugers Arch. 453, 661 (2007), Abstract;

Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies: G.L. Scheffer, et al.; Cancer Res. 60, 5269 (2000), Abstract; Full Text

General Literature References

Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines: M. Kool, et al.; Cancer Res. 57, 3537 (1997), Abstract;