Product Details
| Alternative Name: | Multidrug resistance-associated protein 1, ABCC1 |
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| Clone: | QCRL-3 |
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| Host: | Mouse |
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| Isotype: | IgG2a |
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| Immunogen: | Membranes prepared from the human small cell lung cancer cell line H69AR. |
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| UniProt ID: | P33527 |
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| Species reactivity: | Human
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| Specificity: | Recognizes a conformation-dependent internal epitope (aa 617-932) of human MRP1 (multidrug resistance-associated protein 1), overexpressed in various human non-P-glycoprotein MDR tumor cell lines. |
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| Crossreactivity: | Does not cross-react with human P-glycoprotein, MDR3 P-glycoprotein, or mouse MRP gene products. |
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| Applications: | Flow Cytometry, ICC, IHC (PS), IP, FUNC
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| Application Notes: | Flow Cytometry: cell permeabilization required
Immunocytochemistry: cytospin preparations
Functional Application: inhibits LTC4 transport
Not recommended for Western blot. |
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| Formulation: | Liquid. 0.22µm-filtered antibody in PBS containing 0.7% BSA and 0.1% sodium azide. |
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| Handling: | Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C. |
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| Shipping: | Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
ATP- and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1: J. Renes, et al.; Br. J. Pharmacol.
126, 681 (1999),
Abstract;
Monoclonal antibodies that inhibit the transport function of the 190-kDa multidrug resistance protein, MRP. Localization of their epitopes to the nucleotide-binding domains of the protein: D.R. Hipfner, et al.; J. Biol. Chem.
274, 15420 (1999),
Abstract;
Full Text
MRP expression in acute myeloid leukemia. An update: M. Filipits, et al.; Adv. Exp. Med. Biol.
457, 141 (1999),
Abstract;
Structural, mechanistic and clinical aspects of MRP1: D.R. Hipfner, et al.; Biochim. Biophys. Acta
1461, 359 (1999),
Abstract;
MRP and MDR1 gene expression in primary breast carcinomas: M. Filipits, et al.; Clin. Cancer Res.
2, 1231 (1996),
Abstract;
Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport: D.W. Loe, et al.; J. Biol. Chem.
271, 9675 (1996),
Abstract;
Full Text
Characterization of the M(r) 190,000 multidrug resistance protein (MRP) in drug-selected and transfected human tumor cell: K.C. Almquist, et al.; Cancer Res.
55, 102 (1995),
Abstract;
Detection of the M(r) 190,000 multidrug resistance protein, MRP, with monoclonal antibodies: D.R. Hipfner, et al.; Cancer Res.
54, 5788 (1994),
Abstract;
