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MVP/LRP (human) monoclonal antibody (LRP-56)

ALX-801-005-C100 100 µg 929.00 USD
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Product Details

Alternative Name:Major vault protein/Lung resistance protein
Immunogen:Human MVP/LRP (major vault protein/lung resistance protein).
UniProt ID:Q14764
Species reactivity:Human
Specificity:Recognizes an internal epitope (P110) of human MVP/LRP, which is overexpressed in various human non-P-glycoprotein MDR tumor cell lines.
Applications:Flow Cytometry, ICC, IHC (FS), IHC (PS)
Recommended Dilutions/Conditions:Recommended starting dilution is 1:20. Suggested dilutions/conditions may not be available for all applications. Optimal should be determined individually for each application.
Application Notes:Flow Cytometry: cell permeabilization required)
Immunocytochemistry: cytospin preparations
Positive Control:Cell lines: Appropriate drug-sensitive parental cell lines and their multdrug resistant derivatives prepared by the same methods as the test specimens should be used as control materials.
Tissue: Human colon, kidney, bronchus or adrenal are recommended.
Formulation:Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide.
Shipping:Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only
MVP/LRP (human) monoclonal antibody (LRP-56) image
Figure: Liver cells stained with LRP-56 (ALX-801-005).
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MVP/LRP (human) monoclonal antibody (LRP-56) image

Product Literature References

The formation of vault-tubes: a dynamic interaction between vaults and vault PARP: A. Van Zon, et al.; J. Cell Sci. 116, 4391 (2003), Abstract;
Detection of the Mr 110,000 lung resistance-related protein LRP/MVP with monoclonal antibodies: A.B. Schroeijers, et al.; J. Histochem. Cytochem. 49, 1379 (2001), Abstract;
Immunohistochemical analysis of drug resistance-associated proteins in ovarian carcinomas: D. Mayr, et al.; Pathol. Res. Pract. 196, 469 (2000), Abstract;
The Mr 193,000 vault protein is up-regulated in multidrug-resistant cancer cell lines: A.B. Schroeijers, et al.; Cancer Res. 60, 1104 (2000), Abstract; Full Text
Immunohistochemical detection of the human major vault protein LRP with two monoclonal antibodies in formalin-fixed, paraffin-embedded tissues: A.B. Schroeijers, et al.; Am. J. Pathol. 152, 373 (1998), Abstract;
Identification of novel drug resistance-associated proteins by a panel of rat monoclonal antibodies: M.J. Flens, et al.; Int. J. Cancer 73, 249 (1997), Abstract;
Membrane transport proteins associated with drug resistance expressed in human melanoma: D. Schadendorf, et al.; Am. J. Pathol. 147, 1545 (1995), Abstract;
Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance: R.J. Scheper, et al.; Cancer Res. 53, 1475 (1993), Abstract;

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