Phytotoxin. Causes plant cell necrosis at nanomolar concentrations. Demonstrated to be produced by bacterial nitric oxide synthases (NOS).
Product Specification
| Alternative Name: | Thaztomin A |
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| Formula: | C22H22N4O6 |
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| MW: | 438.4 |
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| Source: | Isolated from Streptomyces bottropensis. |
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| CAS: | 122380-18-1 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by 1H-NMR. |
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| Appearance: | Yellow powder. |
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| Solubility: | Soluble in DMSO or dimethyl formamide; partially soluble in methanol or 100% ethanol; |
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| Shipping: | Shipped on Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored at -20°C. |
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| Handling: | After reconstitution protect from light at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Thaxtomin A induces programmed cell death in Arabidopsis thaliana suspension-cultured cells: I. Duval, et al.; Planta
222, 820 (2005),
Abstract;
Nitration of a peptide phytotoxin by bacterial nitric oxide synthase: J.A. Kers, et al.; Nature
429, 79 (2004),
Abstract;
An Arabidopsis mutant resistant to thaxtomin A, a cellulose synthesis inhibitor from Streptomyces species: W.R. Scheible, et al.; Plant Cell
15, 1781 (2003),
Abstract;
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More chemistry of the thaxtomin phytotoxins: R.R. King, et al.; Phytochemistry
64, 1091 (2003),
Abstract;
Involvement of a cytochrome P450 monooxygenase in thaxtomin A biosynthesis by Streptomyces acidiscabies: F.G. Healy, et al.; J. Bacteriol.
184, 2019 (2002),
Abstract;
Full Text
Selection and characterization of microorganisms utilizing thaxtomin A, a phytotoxin produced by streptomyces scabies: C.L. Doumbou, et al.; Appl. Environ. Microbiol.
64, 4313 (1998),
Abstract;
Full Text
