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Mycotoxin. Induces DNA damage and apoptosis. Increases blood-brain barrier permeability and inhibits monoamine oxidase activity in the brain.
Product Details
| Alternative Name: | 4β,15-Diacetoxy-3α-hydroxy-8α-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-ene |
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| Formula: | C24H34O9 |
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| MW: | 466.5 |
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| Source: | Isolated from Fusarium Sporotrichoides. |
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| CAS: | 21259-20-1 |
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| RTECS: | YD0100000 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White to off-white crystalline solid. |
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| Solubility: | Soluble in methylene chloride (5mg/ml) or chloroform. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Iturin A Strongly Inhibits the Growth and T-2 Toxin Synthesis of Fusarium oxysporum: A Morphological, Cellular, and Transcriptomics Study: M. Hua, et al.; Foods
12, 1278 (2023),
Abstract;
Mycotoxin occurrence on baled and pit silages collected in Co. Meath: C. McElinney, et al.; Irish J. Agr. Food. Res.
54, 87 (2015),
Application(s): Liquid chromatography tandem mass spectrometry for Mycotoxin analysis,
Full Text
Cytotoxicity and related effects of T-2 toxin on cultured Vero cells: C. Bouaziz, et al.; Toxicon
48, 343 (2006),
Abstract;
Development of apoptosis and changes in lymphocyte subsets in thymus, mesenteric lymph nodes and Peyer’s patches of mice orally inoculated with T-2 toxin: T. Nagata, et al.; Exp. Toxicol. Pathol.
53, 309 (2001),
Abstract;
Kinetics of apoptosis-related genes mRNA expression in the dorsal skin of hypotrichotic WBN/ILA-ht rats after topical application of T-2 toxin: S.M. Albarenque, et al.; Exp. Toxicol. Pathol.
52, 553 (2001),
Abstract;
Kinetics and distribution of transforming growth factor (TGF)-beta 1 mRNA in the dorsal skin of hypotrichotic WBN/ILA-Ht rats following topical application of T-2 toxin: S.M. Albarenque, et al.; Exp. Toxicol. Pathol.
52, 297 (2000),
Abstract;
Thymocyte apoptosis by T-2 toxin in vivo in mice is independent of Fas/Fas ligand system: A.M. Murshedul, et al.; Biosci. Biotechnol. Biochem.
64, 210 (2000),
Abstract;
T-2 toxin induces thymic apoptosis in vivo in mice: Z. Islam, et al.; Toxicol. Appl. Pharmacol.
148, 205 (1998),
Abstract;
T-2 toxin-induced apoptosis in hematopoietic tissues of mice: J. Shinozuka, et al.; Toxicol. Pathol.
26, 674 (1998),
Abstract;
Apoptotic cellular damage in mice after T-2 toxin-induced acute toxicosis: T. Ihara, et al.; Nat. Toxins
5, 141 (1997),
Abstract;
T-2 toxin-induced apoptosis in lymphoid organs of mice: J. Shinozuka, et al.; Exp. Toxicol. Pathol.
49, 387 (1997),
Abstract;
The structures of toxins from two strains of Fusarium tricinctum: J.R. Bamburg, et al.; Tetrahedron
24, 3329 (1968),
Abstract;
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