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Ochratoxin A

Mycotoxin. Nephrotoxic.
ALX-630-089-M001 1 mg 77.00 USD
ALX-630-089-M005 5 mg 295.00 USD
ALX-630-089-M025 25 mg 1,075.00 USD
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Mycotoxin. Natural contaminant of mouldy food and feed. It has a number of toxic effects, the most prominent being nephrotoxicity. Immunosuppressive, genotoxic, teratogenic and carcinogenic. Stimulates lipid peroxidation. Induces oxidative DNA lesions coupled with direct DNA adducts via quinone formation.

Product Details

Source:Isolated from Aspergillus ochraceus.
MI:14: 6740
Purity:≥98% (HPLC, TLC)
Appearance:White to off-white crystalline powder.
Solubility:Soluble in methanol (10mg/ml).
Shipping:Ambient Temperature
Long Term Storage:+4°C
Regulatory Status:RUO - Research Use Only
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Product Literature References

Electrochemical Aptamer-Based Sensors for Rapid Point-of-Use Monitoring of the Mycotoxin Ochratoxin A Directly in a Food Stream: J. Somerson, et al.; Molecules 23, 912 (2018), Abstract; Full Text
In vitro selection of an XNA aptamer capable of small-molecule recognition: A.E. Rangel, et al.; Nucleic Acids Res. 46, 8057 (2018), Abstract; Full Text
Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans: A. Pfohl-Leszkowicz & R. A. Manderville; Mol. Nutr. Food Res. 51, 61 (2007), (Review), Abstract;
Toxicokinetics and toxicodynamics of ochratoxin A, an update: D. Ringot, et al.; Chem. Biol. Interact. 159, 18 (2006), (Review), Abstract;
How aspartame prevents the toxicity of ochratoxin A: E.E. Creppy, et al.; J. Toxicol. Sci. 23 Supp. 2, 165 (1998), Abstract;
Toxicity and metabolism of ochratoxin A: J. Fink-Gremmels, et al.; Nat. Toxins 3, 214 (1995), Abstract;
Effect of superoxide dismutase and catalase on the nephrotoxicity induced by subchronical administration of ochratoxin A in rats: I. Baudrimont, et al.; Toxicology 89, 101 (1994), Abstract;
Role of cytochrome P-450 in ochratoxin A-stimulated lipid peroxidation: R.F. Omar, et al.; J. Biochem. Toxicol. 6, 203 (1991), Abstract;
Mechanism of ochratoxin A stimulated lipid peroxidation: R.F. Omar, et al.; Biochem. Pharmacol. 40, 1183 (1990), Abstract;
Lipid peroxidation as a possible cause of ochratoxin A toxicity: A.D. Rahimtula, et al.; Biochem. Pharmacol. 37, 4469 (1988), Abstract;
Ochratoxin A, a toxic metabolite produced by Aspergillus ochraceus Wilh: K.J. van der Merwe, et al.; Nature 205, 112 (1965), Abstract;

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