Mycotoxin. Natural contaminant of mouldy food and feed. It has a number of toxic effects, the most prominent being nephrotoxicity. Immunosuppressive, genotoxic, teratogenic and carcinogenic. Stimulates lipid peroxidation. Induces oxidative DNA lesions coupled with direct DNA adducts via quinone formation.
Product Details
| Formula: | C20H18ClNO6 |
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| MW: | 403.8 |
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| Source: | Isolated from Aspergillus ochraceus. |
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| CAS: | 303-47-9 |
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| MI: | 14: 6740 |
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| RTECS: | AY4375000 |
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| Purity: | ≥98% (HPLC, TLC) |
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| Appearance: | White to off-white crystalline powder. |
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| Solubility: | Soluble in methanol (10mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Electrochemical Aptamer-Based Sensors for Rapid Point-of-Use Monitoring of the Mycotoxin Ochratoxin A Directly in a Food Stream: J. Somerson, et al.; Molecules
23, 912 (2018),
Abstract;
Full Text
In vitro selection of an XNA aptamer capable of small-molecule recognition: A.E. Rangel, et al.; Nucleic Acids Res.
46, 8057 (2018),
Abstract;
Full Text
Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans: A. Pfohl-Leszkowicz & R. A. Manderville; Mol. Nutr. Food Res.
51, 61 (2007), (Review),
Abstract;
Toxicokinetics and toxicodynamics of ochratoxin A, an update: D. Ringot, et al.; Chem. Biol. Interact.
159, 18 (2006), (Review),
Abstract;
How aspartame prevents the toxicity of ochratoxin A: E.E. Creppy, et al.; J. Toxicol. Sci.
23 Supp. 2, 165 (1998),
Abstract;
Toxicity and metabolism of ochratoxin A: J. Fink-Gremmels, et al.; Nat. Toxins
3, 214 (1995),
Abstract;
Effect of superoxide dismutase and catalase on the nephrotoxicity induced by subchronical administration of ochratoxin A in rats: I. Baudrimont, et al.; Toxicology
89, 101 (1994),
Abstract;
Role of cytochrome P-450 in ochratoxin A-stimulated lipid peroxidation: R.F. Omar, et al.; J. Biochem. Toxicol.
6, 203 (1991),
Abstract;
Mechanism of ochratoxin A stimulated lipid peroxidation: R.F. Omar, et al.; Biochem. Pharmacol.
40, 1183 (1990),
Abstract;
Lipid peroxidation as a possible cause of ochratoxin A toxicity: A.D. Rahimtula, et al.; Biochem. Pharmacol.
37, 4469 (1988),
Abstract;
Ochratoxin A, a toxic metabolite produced by Aspergillus ochraceus Wilh: K.J. van der Merwe, et al.; Nature
205, 112 (1965),
Abstract;
