Originally isolated from Nephila maculata. Specific, irreversible spider neurotoxin, that inhibits both glutamate and postsynaptic potentials in the neuromuscular junction. Specifically blocks Na+-channels.
Product Details
| Alternative Name: | 2,4-Dihydroxyphenylacetyl-L-asparaginyl-N'-(L-arginyl-puteanyl)-cadaverine |
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| Formula: | C30H52N10O7 |
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| MW: | 664.8 |
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| Source: | Synthetic. |
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| Purity: | ≥98% (HPLC, TLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in 0.1% acetic acid solution. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | We do not recommend storing aqueous solutions for more than a few weeks. |
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| Handling: | Protect from light. After reconstitution, prepare aliquots and store at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Novel mechanism of blocking axonal Na(+) channels by three macrocyclic polyamine analogues and two spider toxins: M. Yakehiro, et al.; Br. J. Pharmacol.
132, 63 (2001),
Abstract;
Total synthesis of nstx-3, spider toxin of nephila maculata : T. Teshima, et al.; Tetrahedron 47, 3305 (1991),
Characterization of binding sites for spider toxin, [3H]NSTX-3, in the rat brain: H. Ino, et al.; Neurosci. Res.
8, 29 (1990),
Abstract;
Synthesis of a new neurotoxin NSTX-3 of Papua New Guinean spider: T. Teshima, et al.; THL 28, 3509 (1987),
Evidence for a displaceable non-specific [3H]neurotensin binding site in rat brain: Y. Aramaki, et al.; Proc. Jpn. Acad. 62B, 359 (1986),
