Potent inhibitor of microtubule assembly. Antineoplastic glucoside. Antitumor agent. DNA topoisomerase II inhibitor.
Product Details
| Formula: | C22H22O8 |
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| MW: | 414.4 |
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| Source: | Isolated from Podophyllum peltatum. |
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| CAS: | 518-28-5 |
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| MI: | 14: 7546 |
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| RTECS: | LV2500000 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by 1H-NMR and LC-MS. |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in chloroform, 100 % ethanol, acetone or dichloromethane; insoluble in water. |
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| Shipping: | Ambient |
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| Long Term Storage: | +4°C |
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| Handling: | Very hygroscopic. Protect from moisture. Keep under inert gas. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
An evidence-based review of medical and surgical treatments of genital warts.: N. Scheinfeld & DS. Lehman; Dermatol. Online J.
12, 5 (2006),
Abstract;
Er:YAG laser followed by topical podophyllotoxin for hard-to-treat palmoplantar warts.: U. Wollina; Cosmet. Laser Ther.
5, 35 (2003),
Abstract;
Antineoplastic and antiviral activities of podophyllotoxin related lignans: M. Gordaliza, et al.; Arch. Pharmacol.
327, 175 (1994),
Abstract;
Podophyllotoxin, steganacin and combretastatin: natural products that bind at the colchicine site of tubulin: D.L. Sackett; Pharmacol. Therap.
59, 163 (1993),
Abstract;
Antitumor agents. I. DNA topoisomerase II inhibitory activity and the structural relationship of podophyllotoxin derivatives as antitumor agents: T. Terada, et al.; Chem. Pharm. Bull. (Tokyo)
40, 2720 (1992),
Abstract;
Podophyllotoxin-resistant mutants of Chinese hamster ovary cells: cross- resistance studies with various microtubule inhibitors and podophyllotoxin analogues: R.S. Gupta; Cancer Res.
43, 505 (1983),
Abstract;
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