Potent neurotoxin. Small conductance Cl- channel blocker. Highly specific marker for glioma cells and tumors of neuroectodermal origin. Inhibits the activity of matrix metalloproteinase-2 (MMP-2).
Product Details
| Sequence: | H-Met-Cys-Met-Pro-Cys-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys-Asp-Asp-Cys-Cys-Gly-Gly-Lys-Gly-Arg-Gly-Lys-Cys-Tyr-Gly-Pro-Gln-Cys-Leu-Cys-Arg-NH2
(Disulfide bonds between Cys2-Cys19, Cys5-Cys28, Cys16-Cys33and Cys20-Cys35) |
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| Formula: | C158H249N52O48S11 |
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| MW: | 3995.8 |
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| Source: | Synthetic. |
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| CAS: | 163515-35-3 |
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| Quantity: | Vial contains exactly 0.55mg (0.14µmol) |
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| Purity: | ≥98% (TLC, HPLC) |
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| Appearance: | Lyophilized. |
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| Solubility: | Soluble in water |
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| Reconstitution: | Reconstitute by injecting 1.4ml of distilled water into the vial using a calibrated syringe. Then dissolve the contents thoroughly to receive a 10-4 M solution. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Aliquots are stable for a few weeks when stored at -20°C. |
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| Handling: | After reconstitution, prepare aliquots and store at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Targeted delivery of antitumoral therapy to glioma and other malignancies with synthetic chlorotoxin (TM-601): A. N. Mamelak & D. B. Jacoby; Expert Opin. Drug Deliv.
4, 175 (2007), (Review),
Abstract;
Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2: J. Deshane, et al.; J. Biol. Chem.
278, 4135 (2003),
Abstract;
Chlorotoxin, a scorpion-derived peptide, specifically binds to gliomas and tumors of neuroectodermal origin: S.A. Lyons, et al.; Glia
39, 162 (2002),
Abstract;
Use of chlorotoxin for targeting of primary brain tumors: L. Soroceanu, et al.; Cancer Res.
58, 4871 (1998),
Abstract;
NMR sequential assignments and solution structure of chlorotoxin, a small scorpion toxin that blocks chloride channels: G. Lippens, et al.; Biochemistry
34, 13 (1995),
Abstract;
Purification and characterization of chlorotoxin, a chloride channel ligand from the venom of the scorpion: J.A. DeBin, et al.; Am. J. Physiol.
264, C361 (1993),
Abstract;
