Replaces Prod. #: BML-CA450
Induces the release of intracellular Ca2+ . Ryanodine receptors mediate adenine nucleotide, Ca2+ and caffeine-sensitive release of Ca2+ from sarcoplasmic reticulum of cardiac and skeletal muscle and may also mediate intracellular Ca2+ release in neurons. Biphasic effect on sarcoplasmic reticulum calcium channels; Nanomolar levels open the channel and micromolar levels close it.
Product Details
| Formula: | C25H35NO9 |
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| MW: | 493.5 |
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| Source: | Isolated from Ryania speciosa, Flacourtiaceae. |
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| CAS: | 15662-33-6 |
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| MI: | 14: 8307 |
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| RTECS: | VM4025000 |
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| Purity: | ≥99% (HPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in methanol or DMSO (>29mg/ml), in 100% ethanol (16mg/ml); slightly soluble in water (warm). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Increased calcium leak associated with reduced calsequestrin expression in hyperthyroid cardiomyocytes: D.R. de Alba-Aguayo, et al.; Cell Calcium
62, 29 (2017),
Abstract;
Selective inhibition of phosphodiesterase 1 relaxes urinary bladder smooth muscle: role for ryanodine receptor-mediated BK channel activation: W. Xin, et al.; Am. J. Physiol. Cell Physiol.
303, C1079 (2012),
Application(s): ELISA analysis of guinea pig and human DSM cells,
Abstract;
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Involvement of ryanodine receptors in neurotrophin-induced hippocampal synaptic plasticity and spatial memory formation: T. Adasme, et al.; PNAS U.S.A.
108, 3029 (2011),
Abstract;
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The interaction of ryanoids with individual ryanodine receptor channels: A. J. Williams and B. Tanna; Biol. Res.
37, 527 (2004),
Abstract;
The pharmacology of ryanodine and related compounds: J. L. Sutko, et al.; Pharmacol. Rev.
49, 53 (1997),
Abstract;
Cyclic ADP-ribose: a new way to control calcium: A. Galione; Science
259, 325 (1993),
Abstract;
The ryanodine receptor/Ca2+ release channel: P.S. McPherson & K.P. Campbell; J. Biol. Chem.
268, 13765 (1993),
Abstract;
Ryanodine as a functional probe of the skeletal muscle sarcoplasmic reticulum Ca2+ release channel: G. Meissner & A. el-Hashem; Mol. Cell. Biochem.
114, 119 (1992),
Abstract;
The brain ryanodine receptor: a caffeine-sensitive calcium release channel: P.S. McPherson et al.; Neuron
7, 17 (1991),
Abstract;
Depolarization promotes caffeine induced [3H]-noradrenaline release in calcium-free solution from peripheral sympathetic nerves: P.T. Toth et al.; Cell. Calcium
11, 557 (1990),
Abstract;
Rapid kinetic analysis of the calcium-release channels of skeletal muscle sarcoplasmic reticulum: the effect of inhibitors: G. Calviello & M. Chiesi ; Biochemistry
28, 1301 (1989),
Abstract;
Structural aspects of ryanodine action and selectivity: A.L. Waterhouse, et al.; J. Med. Chem.
30, 710 (1987),
Abstract;
Mechanism of action of ryanodine on cardiac sarcoplasmic reticulum: J.J. Feher & G.B. Lipford; Biochim. Biophys. Acta
813, 77 (1985),
Abstract;
Rapid flow chemical quench studies of calcium release from isolated sarcoplasmic reticulum: N. Ikemoto et al.; J. Biol. Chem.
260, 14096 (1985),
Abstract;
Ryanodine: a modifier of sarcoplasmic reticulum calcium release in striated muscle: J.L. Sutko, et al.; Fed. Prod.
44, 2984 (1985),
Abstract;
The calcium-ryanodine receptor complex of skeletal and cardiac muscle: I.N. Pessah, et al.; BBRC
128, 449 (1985),
Abstract;
Ryanodine modification of cardiac muscle responses to potassium-free solutions. Evidence for inhibition of sarcoplasmic reticulum calcium release: J.L. Sutko & J.L. Kenyon; J. Gen. Physiol.
82, 385 (1983),
Abstract;
The pharmacology of ryanodine: D.J. Jenden & A.S. Fairhurst; Pharmacol. Rev.
21, 1 (1969), (Review),
Abstract;
