Potent and selective blocker of the high conductance Ca2+-activated K+ channels.
Product Details
| Alternative Name: | IbTx |
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| Sequence: | Pyr-Phe-Thr-Asp-Val-Asp-Cys-Ser-Val-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys-Met-Gly-Lys-Lys-Cys-Arg-Cys-Tyr-Gln-OH
(Disulfide bonds between Cys7-Cys28, Cys13-Cys33 and Cys17-Cys35) |
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| Formula: | C179H274N50O55S7 |
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| MW: | 4230.9 |
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| Source: | Synthetic. From Buthus tamulus. |
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| CAS: | 129203-60-7 |
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| Quantity: | 0.11mg (25nmol) |
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| Concentration: | 0.1mM after reconstitution. |
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| Formulation: | Lyophilized from aqueous acetic acid solution. |
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| Purity: | ≥94% (HPLC) |
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| Reconstitution: | Do not remove the cap. Inject 260μl distilled water into the vial using a calibrated syringe. Dissolve the contents thouroughly. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | The undissolved peptide is stable at -20°C for more than 1 year. The aqueous solution should be used within a few weeks. |
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| Handling: | After reconstitution, prepare aliquots and store at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Description and role in proliferation of iberiotoxin-sensitive currents in different human mammary epithelial normal and cancerous cells: S. Roger, et al.; Biochim. Biophys. Acta
1667, 190 (2004),
Abstract;
Iberiotoxin-induced block of Ca2+-activated K+ channels induces dihydropyridine sensitivity of ACh release from mammalian motor nerve terminals: M. T. Flink & W. D. Atchison; J. Pharmacol. Exp. Ther.
305, 646 (2003),
Abstract;
Interaction of agitoxin2, charybdotoxin, and iberiotoxin with potassium channels: selectivity between voltage-gated and Maxi-K channels: Y. D. Gao & M. L. Garcia; Proteins
52, 146 (2003),
Abstract;
Synthesis and biological characterisation of a series of iberiotoxin analogues: J.P. Flinn, et al.; Int. J. Pept. Protein Res.
45, 320 (1995),
Abstract;
Synthetic charybdotoxin-iberiotoxin chimeric peptides define toxin binding sites on calcium-activated and voltage-dependent potassium channels: K.M. Gianciacomo, et al.; Biochemistry
32, 2363 (1993),
Abstract;
Mode of action of iberiotoxin, a potent blocker of the large conductance Ca(2+)-activated K+ channel: S. Candia, et al.; Biophys. J.
63, 583 (1992),
Abstract;
Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus: A. Galvez, et al.; J. Biol. Chem.
265, 11083 (1990),
Abstract;
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