Selective P-type Ca2+ channel blocker. Fast acting and potent neurotoxin.
Product Details
| Sequence: | H-Lys-Lys-Lys-Cys-Ile-Ala-Lys-Asp-Tyr-Gly-Arg-Cys-Lys-Trp-Gly-Gly-Thr-Pro-Cys-Cys-Arg-Gly-Arg-Gly-Cys-Ile-Cys-Ser-Ile-Met-Gly-Thr-Asn-Cys-Glu-Cys-Lys-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Gly-Leu-Ala-OH
(Disulfide bonds between Cys4-Cys20, Cys12-Cys25, Cys19-Cys36 and Cys27-Cys34) |
| |
| Formula: | C217H360N68O60S10 |
| |
| MW: | 5202.3 |
| |
| Source: | Synthetic. Originally isolated from Agelenopsis aperta. |
| |
| CAS: | 145017-83-0 |
| |
| RTECS: | AW8050000 |
| |
| Purity: | ≥98% |
| |
| Appearance: | Lyophilized. |
| |
| Solubility: | Soluble in water. |
| |
| Shipping: | Ambient |
| |
| Long Term Storage: | -20°C |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Product Literature References
Agatoxin-IVA-sensitive calcium channels mediate the presynaptic and postsynaptic nicotinic activation of cardiac vagal neurons: J. Wang, et al.; J. Neurophysiol.
85, 164 (2001),
Abstract;
P/Q-type Ca2+ channel blocker omega-agatoxin IVA protects against brain injury after focal ischemia in rats: K. Asakura, et al.; Brain Res.
776, 140 (1997),
Abstract;
Exocytotic Ca2+ channels in mammalian central neurons: K. Dunlap, et al.; TINS
18, 89 (1995), (Review),
Abstract;
Calcium channel diversity and neurotransmitter release: the omega-conotoxins and omega-agatoxins: B.M. Olivera, et al.; Ann. Rev. Biochem.
63, 823 (1994),
Abstract;
Different types of calcium channels mediate central synaptic transmission: T. Takahashi & A. Momiyama; Nature
366, 156 (1993),
Abstract;
Interactions of polyamines with neuronal ion channels: R.H. Scott, et al.; TINS
16, 153 (1993), (Review),
Abstract;
Sequential assignment and structure determination of spider toxin omega- Aga-IVB: H. Yu, et al.; Biochemistry
32, 13123 (1993),
Abstract;
Synthesis of omega-agatoxin IVA and its related peptides: H. Nishio, et al.; BBRC
196, 1447 (1993),
Abstract;
Calcium channels coupled to glutamate release identified by omega-Aga- IVA: T.J. Turner, et al.; Science
258, 310 (1992),
Abstract;
P-type calcium channels blocked by the spider toxin omega-Aga-IVA: I.M. Mintz, et al.; Nature
355, 827 (1992),
Abstract;
