Irreversible, cell permeable, biotin-labelled inhibitor of cysteine proteases.
Product Specification
| Alternative Name: | Dibenzyl-1-[(R)-biotin-6-aminohexanoyl-aziridine]-2,3-(S,S+R,R)-dicarboxylate |
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| Formula: | C34H42N4O7S |
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| MW: | 650.8 |
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| CAS: | 744207-03-2 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to yellow solid. |
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| Solubility: | Soluble in DMSO (50mg/ml), 100% ethanol or methanol. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Aziridine-2,3-dicarboxylate-based cysteine cathepsin inhibitors induce cell death in Leishmania major associated with accumulation of debris in autophagy-related lysosome-like vacuoles: U. Schurigt, et al.; Antimicrob. Agents Chemother.
54, 5028 (2010),
Abstract;
Blocking effect of a biotinylated protease inhibitor on the egress of Plasmodium falciparum merozoites from infected red blood cells: C. Gelhaus, et al.; Biol. Chem.
386, 499 (2005),
Abstract;
Synthesis and antiplasmodial activity of a cysteine protease-inhibiting biotinylated aziridine-2,3-dicarboxylate: C. Gelhaus, et al.; Biol. Chem.
385, 435 (2004),
Abstract;
