Chemiluminescent probe for the detection of superoxide in biological systems.
Product Details
| Alternative Name: | bis-N-Methylacridinium nitrate, N,N'-Dimethyl-9,9'-biacridinium dinitrate |
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| Formula: | C28H22N4O6 |
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| MW: | 510.5 |
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| CAS: | 2315-97-1 |
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| Purity: | ≥97% (HPLC) |
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| Appearance: | Off-white to brown powder. |
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| Solubility: | Soluble in DMSO (~12mg/ml), 100% ethanol (~0.5mg/ml) or acetic acid (~10mg/ml, heat up solution). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
PKC/NADPH oxidase are involved in the protective effect of pioglitazone in high homocysteine-induced paracrine dyfunction in endothelial progenitor cells: S. Xu, et al.; Am. J. Transl. Res.
9, 1037 (2017),
Abstract;
Full Text
Globular adiponectin attenuates LPS-induced reactive oxygen species production in HepG2 cells via FoxO3A and HO-1 signaling: A. Shrestha & P.H. Park; Life Sci.
148, 71 (2016),
Application(s): Cell culture,
Abstract;
Crucial Role of Membrane Type 1 Matrix Metalloproteinase (MT1- MMP) in RhoA/Rac1-Dependent Signaling Pathways in Thrombin- Stimulated Endothelial Cells: K. Ando, et al.; J. Atheroscler. Thromb.
18, 762 (2011),
Abstract;
Full Text
In retinal vein occlusion platelet response to thrombin is increased: G. Leoncini, et al.; Thromb Res.
124, e48 (2009),
Abstract;
Chemiluminescent detection of oxidants in vascular tissue. Lucigenin but not coelenterazine enhances superoxide formation: M.M. Tarpey, et al.; Circ. Res.
84, 1203 (1999),
Abstract;
Lucigenin as a substrate of microsomal NAD(P)H-oxidoreductases: I.A. Schepetkin; Biochemistry (Mosc.)
64, 25 (1999),
Abstract;
Lucigenin is a mediator of cytochrome C reduction but not of superoxide production: I.B. Afanas'ev, et al.; Arch. Biochem. Biophys.
366, 267 (1999),
Abstract;
Validation of lucigenin as a chemiluminescent probe to monitor vascular superoxide as well as basal vascular nitric oxide production: M.P. Skatchkov, et al.; BBRC
254, 319 (1999),
Abstract;
Lucigenin as mediator of superoxide production: revisited: S.I. Liochev & I. Fridovich; Free Radic. Biol. Med.
25, 926 (1998),
Abstract;
Validation of lucigenin (bis-N-methylacridinium) as a chemilumigenic probe for detecting superoxide anion radical production by enzymatic and cellular systems: Y. Li, et al.; J. Biol. Chem.
273, 2015 (1998),
Abstract;
Full Text
What do we measure with luminol-, lucigenin- and penicillin-amplified chemiluminescence? 1. Investigations with hydrogen peroxide and sodium hypochlorite: M. Rost, et al.; J. Biolumin. Chemilumin.
13, 355 (1998),
Abstract;
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