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Monophosphoryl Lipid A from Salmonella minnesota R595 (Re) (TLRGRADE®) (Ready-to-Use)

TLR4 activator
 
ALX-581-202-R500 500 µl 323.00 USD
 
ALX-581-202-L001 1 ml 445.00 USD
Do you need bulk/larger quantities?
 
Adjuvant

Product Details

Alternative Name:MPL-A from Salmonella minnesota R595 (Re)
 
Source:Isolated from Salmonella minnesota R595 (Re mutant). Prepared by acid hydrolysis from purified Salmonella minnesota R595 (Re) LPS (isolated by a modification of the PCP extraction method), converted to the uniform salt form and dissolved in sterile pyrogen-free double distilled water.
 
Concentration:1mg/ml
 
Formulation:Liquid. Sterile, ready-to-use solution in pyrogen-free double distilled water.
 
Purity:≥99.9% (regarding protein or DNA contaminants; KDO not detectable)
 
Activity:Activates Toll-like receptor (TLR) 4. Does not activate TLR2 as determined with splenocytes and macrophages from TLR4 deficient mice. Exhibits reduced endotoxic and pyrogenic activity compared to lipid A and LPS.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Handling:Keep sterile.
 
Regulatory Status:RUO - Research Use Only
 

Product Literature References

MPL Adjuvant Contains Competitive Antagonists of Human TLR4: Y.Q. Wang, et al.; Front. Immunol. 11, 577823 (2020), Abstract; Full Text
Specific features of human monocytes activation by monophosphoryl lipid A: R. Chentouh, et al.; Sci. Rep. 8, 7096 (2018), Abstract; Full Text
CD14 and TRIF govern distinct responsiveness and responses in mouse microglial TLR4 challenges by structural variants of LPS: T. Regen, et al.; Brain Behav. Immun. 25, 957 (2011), Abstract;
Isolation and purification of R-form lipopolysaccharides: C. Galanos & O. Luderitz; Meth. Carbohydr. Chem. 9, 11 (1993),
Electrodialysis of lipopolysaccharides and their conversion to uniform salt forms: C. Galanos & O. Luderitz; Eur. J. Biochem. 54, 603 (1975), Abstract;
A new method for the extraction of R lipopolysaccharides: C. Galanos, et al.; Eur. J. Biochem. 9, 245 (1969), Abstract;

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