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Nicotinic acetylcholine receptor activator
ALX-550-526-M005 5 mg 170.00 USD
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Type II positive allosteric modulator (PAM) of α7 neuronal nicotinic acetylcholine receptor (nAChR) (EC50=216nM). Shows no detectable effect on α4β2, α3β4 and α9α10 receptors.

Product Details

Alternative Name:NSC 216666, N-(5-Chloro-2,4-dimethoxyphenyl)-N’-(5-methyl-3-isoxazolyl)urea
Purity:≥98% (HPLC)
Identity:Determined by MS and NMR.
Appearance:White to off-white solid.
Solubility:Soluble in DMSO (50mg/ml); slightly soluble in methanol (1mg/ml) or acetonitrile (0.5mg/ml).
Shipping:Ambient Temperature
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only
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Product Literature References

Allosteric Modulators of the alpha7 Nicotinic Acetylcholine Receptor: R. Faghih, et al.; J. Med. Chem. 51, 701 (2008), Abstract;
Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes: J.H. Gronlien, et al.; Mol. Pharmacol. 72, 715 (2007), Abstract;
A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization: R.S. Hurst, et al.; J. Neurosci. 25, 4396 (2005), Abstract; Full Text

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