TRPV1 agonist. Amide based RTX analog. RTX binding affinity (Ki=15nM), high agonism (calcium influx: EC50=0.29nM).
Product Details
| Alternative Name: | N-[2-(4-tert-Butylbenzyl)-3-(pivaloylxy)propyl]-2-[4-hydroxy-3-methoxyphenyl]acetamide |
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| Formula: | C28H39NO5 |
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| MW: | 469.6 |
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| CAS: | 289903-41-9 |
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| Purity: | ≥98% |
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| Appearance: | White sticky solid. |
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| Solubility: | Soluble in methanol, 100% ethanol, DMSO or other organic solvents; insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Structure-activity relationships of simplified resiniferatoxin analogues with potent VR1 agonism elucidates an active conformation of RTX for VR1 binding: J. Lee, et al.; Bioorg. Med. Chem.
12, 1055 (2004),
Abstract;
Phenolic modification as an approach to improve the pharmacology of the 3-acyloxy-2-benzylpropyl homovanillic amides and thioureas, a promising class of vanilloid receptor agonists and analgesics: J. Lee, et al.; Bioorg. Med. Chem.
10, 1171 (2002),
Abstract;
