Potent analgesic with EC50=0.96µg/kg in the acetic acid-induced writhing test. RTX binding affinity (Ki=603nM), agonism (calcium influx; EC50=240nM).
Product Details
| Alternative Name: | N-[2-(3,4-Dimethylbenzyl)-3-(pivalyloxy)propyl]-2-[4-(2-aminoethoxy)-3-methoxyphenyl]acetamide |
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| Formula: | C28H40N2O5 |
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| MW: | 484.6 |
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| CAS: | 289902-82-5 |
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| Purity: | ≥98% |
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| Appearance: | White solid. |
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| Solubility: | Soluble in methanol, 100% ethanol, DMSO or other organic solvents; insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Phenolic modification as an approach to improve the pharmacology of the 3-acyloxy-2-benzylpropyl homovanillic amides and thioureas, a promising class of vanilloid receptor agonists and analgesics: J. Lee, et al.; Bioorg. Med. Chem.
10, 1171 (2002),
Abstract;
