Potent TRPV1 agonist (K
i=11nM). About 500-fold more potent than capsaicin (Prod. No.
BML-EI125). RTX binding affinity (K
i=6.35nM), agonism (calcium influx; EC
50=2.83nM).
Product Specification
| Formula: | C28H40N2O4S |
| |
| MW: | 500.7 |
| |
| CAS: | 289902-71-2 |
| |
| Purity: | ≥98% |
| |
| Appearance: | White solid. |
| |
| Solubility: | Soluble in methanol, 100% ethanol, DMSO or other organic solvents; insoluble in water. |
| |
| Shipping: | Ambient |
| |
| Long Term Storage: | -20°C |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
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Product Literature References
Phenolic modification as an approach to improve the pharmacology of the 3-acyloxy-2-benzylpropyl homovanillic amides and thioureas, a promising class of vanilloid receptor agonists and analgesics: J. Lee, et al.; Bioorg. Med. Chem.
10, 1171 (2002),
Abstract;
N-(3-Acyloxy-2-benzylpropyl)-N'-(4-hydroxy-3-methoxybenzyl) thiourea derivatives as potent vanilloid receptor agonists and analgesics: J. Lee, et al.; Bioorg. Med. Chem.
9, 19 (2001),
Abstract;
