Potent and selective CB2 receptor agonist (Ki=3.4nM (mouse), Ki=280nM (rat) also in vivo.
Product Details
| Alternative Name: | (2-Iodo-5-nitrophenyl)-(1-(1-methylpiperidin-2-ylmethyl)-1H-indol-3-yl)methanone |
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| Formula: | C22H22N3O3I |
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| MW: | 503.3 |
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| CAS: | 444912-48-5 |
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| Purity: | ≥97% (TLC) |
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| Identity: | Determined by NMR. |
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| Appearance: | Yellow powder. |
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| Solubility: | Soluble in DMSO, dimethyl formamide, 100% ethanol or methanol; insoluble in water. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Unstable in 1M NaOH; slightly unstable in 1M HCl. |
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| Handling: | Protect from light. Packaged under inert gas. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Activation of murine microglial N9 cells is attenuated through cannabinoid receptor CB2 signaling: L. Ma, et al.; Biochem. Biophys. Res. Commun.
458, 92 (2015),
Application(s): Cell Culture,
Abstract;
In vitro pharmacological characterization of AM1241: a protean agonist at the cannabinoid CB2 receptor?: B.B. Yao, et al.; Br. J. Pharmacol.
149, 145 (2006),
Abstract;
Selective activation of cannabinoid CB2 receptors suppresses hyperalgesia evoked by intradermal capsaicin: A.G. Hohmann, et al.; J. Pharmacol. Exp. Ther.
308, 446 (2004),
Abstract;
Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS: M.M. Ibrahim, et al.; PNAS
100, 10529 (2003),
Abstract;
Full Text
Inhibition of inflammatory hyperalgesia by activation of peripheral CB2 cannabinoid receptors: A. Quartilho, et al.; Anesthesiology
99, 955 (2003),
Abstract;
Selective activation of cannabinoid CB(2) receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation: A.G. Nackley, et al.; Neuroscience
119, 747 (2003),
Abstract;
CB2 cannabinoid receptor-mediated peripheral antinociception: T.P. Malan, Jr., et al.; Pain
93, 239 (2001),
Abstract;
