Potent and highly selective antagonist for mGluR5 with a 5-fold higher anxiolytic activity than MPEP (Prod. No. ALX-550-368). Shows fewer off-target effects than MPEP.
Product Details
| Formula: | C11H8N2S |
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| MW: | 200.3 |
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| CAS: | 329205-68-7 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to yellow solid. |
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| Solubility: | Soluble in DMSO, 100% ethanol or methanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
In vitro metabolic studies on the selective metabotropic glutamate receptor sub-type 5 (mGluR5) antagonist 3-[(2-methyl-1,3-thiazol-4-yl) ethynyl]-pyridine (MTEP): M.D. Green, et al.; Neurosci. Lett.
391, 91 (2006),
Abstract;
MTEP, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), produces antiparkinsonian-like effects in rats: K. Ossowska, et al.; Neuropharmacology
49, 447 (2005),
Abstract;
Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors: P.M.t. Lea, et al.; Br. J. Pharmacol.
145, 527 (2005),
Abstract;
Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist: A. Palucha, et al.; Pharmacol. Biochem. Behav.
81, 901 (2005),
Abstract;
Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signaling: A. Klodzinska, et al.; Neuropharmacology
47, 342 (2004),
Abstract;
[3H]-Methoxymethyl-MTEP and [3H]-Methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor: N.D. Cosford, et al.; Bioorg. Med. Chem. Lett.
13, 351 (2003),
Abstract;
Reduced stress-induced hyperthermia in mGluR5 knockout mice: J. Brodkin, et al.; Eur. J. Neurosci.
16, 2241 (2002),
Abstract;
[3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization: J.J. Anderson, et al.; J. Pharmacol. Exp. Ther.
303, 1044 (2002),
Abstract;
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