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Memantine . hydrochloride

NMDA receptor antagonist
ALX-550-363-M050 50 mg 93.00 USD
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Low-affinity NMDA receptor antagonist. Stimulates dopamine release.

Product Details

Alternative Name:1-Amino-3,5-dimethyladamantane . HCl, 3,5-Dimethyl-1-aminoadamantane . HCl
Formula:C12H21N . HCl
MW:179.3 . 36.5
MI:14: 5829
Purity:≥98% (Argentmetric Titration)
Appearance:White powder.
Shipping:Ambient Temperature
Long Term Storage:+4°C
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist--a review of preclinical data: C.G. Parsons, et al.; Neuropharmacology 38, 735 (1999), (Review), Abstract;
Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze lea: H.S. Chen, et al.; Neuroscience 86, 1121 (1998), Abstract;
Inhibition of reinforcing effects of morphine and motivational aspects of naloxone-precipitated opioid withdrawal by N-methyl-D-aspartate receptor antagonist, memantine: P. Popik & W. Danysz; J. Pharmacol. Exp. Ther. 280, 854 (1997), Abstract;
Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism: H.S. Chen & S.A. Lipton; J. Physiol. 499, 27 (1997), Abstract;
Trapping channel block of NMDA-activated responses by amantadine and memantine: T.A. Blanpied, et al.; J. Neurophysiol. 77, 309 (1997), Abstract;
Effects of memantine and MK-801 on NMDA-induced currents in cultured neurones and on synaptic transmission and LTP in area CA1 of rat hippocampal slices: T. Frankiewicz, et al.; Br. J. Pharmacol. 117, 689 (1996), Abstract;
Memantine stimulates inositol phosphates production in neurones and nullifies N-methyl-D-aspartate-induced destruction of retinal neurones: N.N. Osborne & G. Quack; Neurochem. Int. 21, 329 (1992), Abstract;
Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity: H.S. Chen, et al.; J. Neurosci. 12, 4427 (1992), Abstract;

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