Low-affinity NMDA receptor antagonist. Stimulates dopamine release.
Product Details
| Alternative Name: | 1-Amino-3,5-dimethyladamantane . HCl, 3,5-Dimethyl-1-aminoadamantane . HCl |
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| Formula: | C12H21N . HCl |
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| MW: | 179.3 . 36.5 |
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| CAS: | 41100-52-1 |
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| MI: | 14: 5829 |
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| Purity: | ≥98% (Argentmetric Titration) |
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| Appearance: | White powder. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist--a review of preclinical data: C.G. Parsons, et al.; Neuropharmacology
38, 735 (1999), (Review),
Abstract;
Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze lea: H.S. Chen, et al.; Neuroscience
86, 1121 (1998),
Abstract;
Inhibition of reinforcing effects of morphine and motivational aspects of naloxone-precipitated opioid withdrawal by N-methyl-D-aspartate receptor antagonist, memantine: P. Popik & W. Danysz; J. Pharmacol. Exp. Ther.
280, 854 (1997),
Abstract;
Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism: H.S. Chen & S.A. Lipton; J. Physiol.
499, 27 (1997),
Abstract;
Trapping channel block of NMDA-activated responses by amantadine and memantine: T.A. Blanpied, et al.; J. Neurophysiol.
77, 309 (1997),
Abstract;
Effects of memantine and MK-801 on NMDA-induced currents in cultured neurones and on synaptic transmission and LTP in area CA1 of rat hippocampal slices: T. Frankiewicz, et al.; Br. J. Pharmacol.
117, 689 (1996),
Abstract;
Memantine stimulates inositol phosphates production in neurones and nullifies N-methyl-D-aspartate-induced destruction of retinal neurones: N.N. Osborne & G. Quack; Neurochem. Int.
21, 329 (1992),
Abstract;
Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity: H.S. Chen, et al.; J. Neurosci.
12, 4427 (1992),
Abstract;
