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(Z)-4-Hydroxytamoxifen

Tamoxifen metabolite



ALX-550-361-M001	1 mg	66.00 USD

ALX-550-361-M005	5 mg	239.00 USD
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Metabolite of tamoxifen (Prod. No. ALX-550-095). Exhibits a more potent estrogen agonist/antagonist activity than the parent drug. Has antioxidant properties. Intramembranous inhibitor of lipid peroxidation.

Product Details

Alternative Name:	(Z)-4-[1-(p-(Dimethylaminoethoxy)phenyl)-2-phenyl-1-butenyl]phenol

Formula:	C₂₆H₂₉NO₂

MW:	387.5

CAS:	68047-06-3, 65213-48-1

Purity:	≥98% (UHPLC)

Identity:	Determined by MS.

Appearance:	White to off-white powder.

Solubility:	Soluble in 100% ethanol (20mg/ml) or methanol (10mg/ml); insoluble water.

Shipping:	Ambient

Long Term Storage:	+4°C

Handling:	Protect from light.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis: L. Mayes-Hopfinger, et al.; Nat. Commun. 12, 4546 (2021), Abstract;

Estrogen and tamoxifen metabolites protect smooth muscle cell membrane phospholipids against peroxidation and inhibit cell growth: R.K. Dubey, et al.; Circ. Res. 84, 229 (1999), Abstract;

Peroxidase-catalyzed pro- versus antioxidant effects of 4-hydroxytamoxifen: enzyme specificity and biochemical sequelae: B.W. Day, et al.; Chem. Res. Toxicol. 12, 28 (1999), Abstract;

Tamoxifen and hydroxytamoxifen as intramembraneous inhibitors of lipid peroxidation. Evidence for peroxyl radical scavenging activity: J.B. Custódio, et al.; Biochem. Pharmacol. 47, 1989 (1994), Abstract;

Protective actions of tamoxifen and 4-hydroxytamoxifen against oxidative damage to human low-density lipoproteins: a mechanism accounting for the cardioprotective action of tamoxifen?: H. Wiseman, et al.; Biochem. J. 292, 635 (1993), Abstract;

Mechanism of inhibition of lipid peroxidation by tamoxifen and 4-hydroxytamoxifen introduced into liposomes. Similarity to cholesterol and ergosterol: H. Wiseman, et al.; FEBS Lett. 274, 107 (1990), Abstract;

The antioxidant action of tamoxifen and its metabolites. Inhibition of lipid peroxidation: H. Wiseman, et al.; FEBS Lett. 263, 192 (1990), Abstract;