Non-pungent resiniferatoxin-type phorboid vanilloid. Agonist at rat TRPV1 (EC50 between 3 and 10µM) but virtually inactive at human TRPV1 (EC50>10µM). Induces apoptosis through a TRPV-independent mechanism. Tumor promotor.
Product Specification
| Alternative Name: | Phorbol 12-phenylacetate 13-acetate 20-homovanillate |
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| Formula: | C39H44O11 |
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| MW: | 688.8 |
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| CAS: | 175796-50-6 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in methanol, 100% ethanol or DMSO; insoluble in water. |
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| Shipping: | Ambient |
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| Long Term Storage: | +4°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Identification of species-specific determinants of the action of the antagonist capsazepine and the agonist PPAHV on TRPV1: E. Phillips, et al.; J. Biol. Chem.
279, 17165 (2004),
Abstract;
Respiratory actions of vanilloid receptor agonists in the nucleus of the solitary tract: comparison of resiniferatoxin with non-pungent agents and anandamide: D.P. Geraghty, et al.; Br. J. Pharmacol.
137, 919 (2002),
Abstract;
Differences in sensitivity of vanilloid receptor 1 transfected to human embryonic kidney cells and capsaicin-activated channels in cultured rat dorsal root ganglion neurons to capsaicin receptor agonists: J.S. Shin, et al.; Neurosci. Lett.
299, 135 (2001),
Abstract;
Pharmacological differences between the human and rat vanilloid receptor 1 (VR1): P. McIntyre, et al.; Br. J. Pharmacol.
132, 1084 (2001),
Abstract;
Characterization using FLIPR of rat vanilloid receptor (rVR1) pharmacology: J.C. Jerman, et al.; Br. J. Pharmacol.
130, 916 (2000),
Abstract;
Functional and desensitizing effects of the novel synthetic vanilloid- like agent 12-phenylacetate 13-acetate 20-homovanillate (PPAHV) in the perfused rat hindlimb: C.D. Griffiths, et al.; Br. J. Pharmacol.
131, 1408 (2000),
Abstract;
Phorboid 20-homovanillates induce apoptosis through a VR1-independent mechanism: A. Macho, et al.; Chem. Biol.
7, 483 (2000),
Abstract;
A non-pungent resiniferatoxin analogue, phorbol 12-phenylacetate 13 acetate 20-homovanillate, reveals vanilloid receptor subtypes on rat trigeminal ganglion neurons: L. Liu, et al.; Neuroscience
84, 569 (1998),
Abstract;
A novel agonist, phorbol 12-phenylacetate 13-acetate 20-homovanillate, abolishes positive cooperativity of binding by the vanilloid receptor: A. Szallasi, et al.; Eur. J. Pharmacol.
299, 221 (1996),
Abstract;
Synthesis and evaluation of phorboid 20-homovanillates: discovery of a class of ligands binding to the vanilloid (capsaicin) receptor with different degrees of cooperativity: G. Appendino, et al.; J. Med. Chem.
39, 3123 (1996),
Abstract;
