Online Purchasing Account You are logged on as Guest. Login Register a New Account Shopping cart (Empty)

Cyclothiazide

AMPA receptor activator



ALX-550-338-M050	50 mg	254.00 USD
Do you need bulk/larger quantities?

Potently inhibits the desensitization of AMPA receptors. Antihypertensive.

Product Details

Alternative Name:	3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, 6-Chloro-3,4-dihydro-3[2-norbornen-5-yl]-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Formula:	C₁₄H₁₆ClN₃O₄S₂

MW:	389.9

CAS:	2259-96-3

MI:	14: 2754

Purity:	≥98% (HPLC (UV))

Appearance:	White to off-white solid.

Solubility:	Soluble in DMSO, methanol (36mg/ml) or dilute aqueous base (36mg/ml); insoluble in water.

Shipping:	Ambient Temperature

Long Term Storage:	+4°C

Regulatory Status:	RUO - Research Use Only

Please mouse over

Product Literature References

Enhanced long term potentiation and decreased AMPA receptor desensitization in the acute period following a single kainate induced early life seizure: H. O'Leary, et al. ; Neurobiol. Dis. 87, 134 (2015), Application(s): Blocked AMPAR desensitization, Abstract;

Cyclothiazide acts at a site on the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor complex that does not recognize competitive or noncompetitive AMPA receptor antagonists: M.A. Desai, et al.; J. Pharmacol. Exp. Ther. 272, 38 (1995), Abstract;

Inhibition by cyclothiazide of neuronal nicotinic responses in bovine chromaffin cells: J.M. Nooney & A. Feltz; Br. J. Pharmacol. 114, 648 (1995), Abstract;

Modulation of AMPA/kainate receptors by cyclothiazide increases cytoplasmic free Ca2+ and 45Ca2+ uptake in brain neurons: G. Cebers & S. Liljequist; Eur. J. Pharmacol. 290, 105 (1995), Abstract;

Cyclothiazide potentiates agonist responses at human AMPA/kainate receptors expressed in oocytes: R.L. Sharp, et al.; Eur. J. Pharmacol. 266, R1 (1994), Abstract;

Desensitization of AMPA receptors upon multiquantal neurotransmitter release: L.O. Trussell, et al.; Neuron 10, 1185 (1993), Abstract;

Differential modulation by cyclothiazide and concanavalin A of desensitization at native alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid- and kainate-preferring glutamate receptors: L.A. Wong & M.L. Mayer; Mol. Pharmacol. 44, 504 (1993), Abstract;