Potent and selective group I mGluR antagonist.
Product Details
| Alternative Name: | S-(+)-2-(3'-Carboxybicyclo[1.1.1]pentyl)glycine, UPF 596 |
| |
| Formula: | C8H11NO4 |
| |
| MW: | 185.2 |
| |
| Purity: | ≥95% (1H-NMR) |
| |
| Appearance: | White solid. |
| |
| Solubility: | Soluble in water or DMSO. |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | +4°C |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
1-Aminoindan-1,5-dicarboxylic acid and (S)-(+)-2-(3'- carboxybicyclo[1.1.1] pentyl)-glycine, two mGlu1 receptor-preferring antagonists, reduce neuronal death in in vitro and in vivo models of cerebral: D.E. Pellegrini-Giampietro, et al.; Eur. J. Neurosci.
11, 3637 (1999),
Abstract;
Biochemical and electrophysiological studies on (S)-(+)-2-(3'- carboxybicyclo[1.1.1]pentyl)-glycine (CBPG), a novel mGlu5 receptor agonist endowed with mGlu1 receptor antagonist activity: G. Mannaioni, et al.; Neuropharmacology
38, 917 (1999),
Abstract;
Metabotropic G-protein-coupled glutamate receptors as therapeutic targets: R. Pellicciari & G. Costantino; Curr. Opin. Chem. Biol.
3, 433 (1999), (Review),
Abstract;
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology
38, 1431 (1999), (Review),
Abstract;
Protection with metabotropic glutamate 1 receptor antagonists in models of ischemic neuronal death: time-course and mechanisms: D.E. Pellegrini-Giampietro, et al.; Neuropharmacology
38, 1607 (1999),
Abstract;
Presynaptic mGlu1 type receptors potentiate transmitter output in the rat cortex: F. Moroni, et al.; Eur. J. Pharmacol.
347, 189 (1998),
Abstract;
(S)-(+)-2-(3'-carboxybicyclo[1.1.1]pentyl)-glycine, a structurally new group I metabotropic glutamate receptor antagonist: R. Pellicciari, et al.; J. Med. Chem.
39, 2874 (1996),
Abstract;
Pharmacological studies on new agonists and antagonists of mGluRs: R. Pellicciari, et al.; Neuropharmacology 35, A21 (1996),
