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CNS stimulant
ALX-550-322-G005 5 g 45.00 USD
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CNS stimulant. Blocks adenosine A1 and A2A receptors. cAMP phosphodiesterase inhibitor. Interferes with the uptake and storage of Ca2+ by the sarcoplasmic reticulum in skeletal muscle. Prevents apoptosis and cell cycle effects induced by various chemicals. Inhibits cellular DNA repair mechanisms. Anti-inflammatory.

Product Details

Alternative Name:1,3,7-Trimethylxanthine, 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
Source:Found in tea leaves, coffee beans, cocoa beans, maté leaves, guarana paste and kola nuts.
MI:14: 1636
Purity:≥99% (HPLC)
Identity:Determined by IR.
Appearance:White to colorless powder.
Solubility:Soluble in chloroform, 100% alcohol or hot water.
Shipping:Ambient Temperature
Long Term Storage:Ambient
Regulatory Status:RUO - Research Use Only
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Product Literature References

A comprehensive study of the differences in protein expression and chemical constituents in tea leaves (Camellia sinensis var. sinensis) with different maturity using a combined proteomics and metabolomics method: Z. Sun, et al.; Food Res. Int. 157, 111397 (2022), Abstract;
New insights into the influences of baking and storage on the nonvolatile compounds in oolong tea: A nontargeted and targeted metabolomics study: J. Peng, et al.; Food Chem. 375, 131872 (2022), Abstract;
Impact of Various Microbial-Fermented Methods on the Chemical Profile of Dark Tea Using a Single Raw Tea Material: J. Shi, et al.; J. Agric. Food Chem. 69, 4210 (2021), Abstract;
Time effect of rutaecarpine on caffeine pharmacokinetics in rats: R.K. Estari, et al.; Biochem. Biophys. Rep. 28, 101121 (2021), Abstract;
Study of the dynamic changes in the Non-volatile chemical constituents of black tea during fermentation processing by a Non-targeted metabolomics approach: J. Tan, et al.; Food Res. Int. 79, 106 (2016),
The enigmatic effects of caffeine in cell cycle and cancer: A. M. & Bode and Z. Dong; Cancer Lett. 247, 26 (2007), (Review), Abstract;
Immunomodulatory effects of caffeine: friend or foe: L. A. Horrigan, et al.; Pharmacol. Ther. 111, 877 (2006), (Review), Abstract;
Novel neuroprotection by caffeine and adenosine A(2A) receptor antagonists in animal models of Parkinson’s disease: A. Kalda, et al.; J. Neurol. Sci. 248, 9 (2006), (Review), Abstract;
Acute effects of caffeine on arterial stiffness, wave reflections, and central aortic pressures: T.G. Papaioannou, et al.; Am. J. Hypertens. 18, 129 (2005), (Review), Abstract;
Caffeine and the dopaminergic system: O. Cauli & M. Morelli; Behav. Pharmacol. 16, 63 (2005), (Review), Abstract;
Caffeine as an analgesic adjuvant: a review of pharmacology and mechanisms of action: J. Sawynok & T.L. Yaksh; Pharmacol. Rev. 45, 43 (1993), Abstract;
Caffeine prevents apoptosis and cell cycle effects induced by camptothecin or topotecan in HL-60 cells: F. Traganos, et al.; Cancer Res. 53, 4613 (1993), Abstract;
Multiple effects of caffeine on calcium current in rat ventricular myocytes: I. Zahradnik & P. Palade; Pfluegers Arch. 424, 129 (1993), Abstract;
Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors: J.W. Daly, et al.; J. Med. Chem. 29, 1305 (1986), Abstract;

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