Selective group II mGluR antagonist.
Product Details
| Alternative Name: | (2S,1'S,2'S,3'R)-2-(2'Carboxy-3'-phenylcyclopropyl)glycine |
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| Formula: | C12H13NO4 |
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| MW: | 235.2 |
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| Purity: | ≥97% |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO; poorly soluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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3, 433 (1999), (Review),
Abstract;
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38, 1431 (1999),
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37, 1465 (1998),
Abstract;
Selective activation of group-II metabotropic glutamate receptors is protective against excitotoxic neuronal death: G. Battaglia, et al.; Eur. J. Pharmacol.
356, 271 (1998),
Abstract;
Opposite influence of the metabotropic glutamate receptor subtypes mGlu3 and -5 on astrocyte proliferation in culture: R. Ciccarelli, et al.; Glia
21, 390 (1997),
Abstract;
PCCG-IV inhibits the induction of long-term potentiation in the dentate gyrus in vitro: L. Huang, et al.; Eur. J. Pharmacol.
332, 161 (1997),
Abstract;
The neuroprotective activity of group-II metabotropic glutamate receptors requires new protein synthesis and involves a glial-neuronal signaling: V. Bruno, et al.; J. Neurosci.
17, 1891 (1997),
Abstract;
Type 2 metabotropic glutamate (mGlu) receptors tonically inhibit transmitter release in rat caudate nucleus: in vivo studies with (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a new potent and selective antagonist: A. Cozzi, et al.; Eur. J. Neurosci.
9, 1350 (1997),
Abstract;
(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a potent and selective antagonist of type 2 metabotropic glutamate receptors: C. Thomsen, et al.; Mol. Pharmacol.
50, 6 (1996),
Abstract;
Asymmetric synthesis of enantiomerically pure (2S,1'S,2'S,3'R)-phenylcarboxycyclopropylglycine (PCCG-4): a potent and selective ligand at group II metabotropic glutamate receptors: M. Marinozzi, et al.; Bioorg. Med. Chem. Lett. 6, 2243 (1996),
Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2'-carboxy-3'-phenylcyclopropyl)glycine. Focus on (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptor: R. Pellicciari, et al.; J. Med. Chem.
39, 2259 (1996),
Abstract;
